Results 71 to 80 of about 403,562 (281)

Predictability of the Arctic sea ice edge [PDF]

, 2016
Skillful sea ice forecasts from days to years ahead are becoming increasingly important for the operation and planning of human activities in the Arctic. Here we analyze the potential predictability of the Arctic sea ice edge in six climate models.
E. Hawkins, Emmerson C., H. F. Goessling, J. J. Day, Onyango J., S. Tietsche, Smith G., T. Jung   +7 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Sensitivity of Arctic Sea Ice Extent to Sea Ice Concentration Threshold Choice and Its Implication to Ice Coverage Decadal Trends and Statistical Projections

Remote Sensing, 2020
Arctic sea ice extent has been utilized to monitor sea ice changes since the late 1970s using remotely sensed sea ice data derived from passive microwave (PM) sensors. A 15% sea ice concentration threshold value has been used traditionally when computing
Jessica L. Matthews, Ge Peng, Walter N. Meier, Otis Brown   +3 more
doaj   +1 more source

Impacts of freshwater changes on Antarctic sea ice in an eddy-permitting sea-ice–ocean model [PDF]

The Cryosphere, 2017
In a warming climate, satellite data indicate that the sea ice extent around Antarctica has increased over the last decades. One of the suggested explanations is the stabilizing effect of increased mass loss of the Antarctic ice sheet.
V. Haid, V. Haid, D. Iovino, S. Masina, S. Masina   +4 more
doaj   +1 more source

Ice core reconstruction of sea ice change in the Amundsen-Ross Seas since 1702 A.D. [PDF]

, 2016
Antarctic sea ice has been increasing in recent decades, but with strong regional differences in the expression of sea ice change. Declining sea ice in the Bellingshausen Sea since 1979 (the satellite era) has been linked to the observed warming on the ...
Abram, Nerilie J., Thomas, Elizabeth R.
core   +1 more source

Assessing uncertainties in sea ice extent climate indicators

Environmental Research Letters, 2019
The uncertainties in sea ice extent (total area covered by sea ice with concentration >15%) derived from passive microwave sensors are assessed in two ways. Absolute uncertainty (accuracy) is evaluated based on the comparison of the extent between several products.
Walter N Meier, J Scott Stewart
openaire   +2 more sources

Fram Strait sea ice export variability and September Arctic sea ice extent over the last 80 years [PDF]

The Cryosphere, 2016
Abstract. A new long-term data record of Fram Strait sea ice area export from 1935 to 2014 is developed using a combination of satellite radar images and station observations of surface pressure across Fram Strait. This data record shows that the long-term annual mean export is about 880 000 km2, representing 10 % of the sea-ice-covered area inside the
Lars H. Smedsrud, Mari H. Halvorsen, Julienne C. Stroeve, Rong Zhang, Kjell Kloster   +4 more
openaire   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

How does internal variability influence the ability of CMIP5 models to reproduce the recent trend in Southern Ocean sea ice extent? [PDF]

The Cryosphere, 2013
Observations over the last 30 yr have shown that the sea ice extent in the Southern Ocean has slightly increased since 1979. Mechanisms responsible for this positive trend have not been well established yet. In this study we tackle two related issues:
V. Zunz, H. Goosse, F. Massonnet
doaj   +1 more source