Results 51 to 60 of about 5,965,886 (309)
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Interface roughness effect on friction map under fretting contact conditions [PDF]
, 2010 In many industrial applications where fretting damage is observed in the contact (e.g. rotor/blade, electrical contacts, assembly joint, axe/wheel, clutch) the external loadings or geometry design cannot be changed. Therefore, the surface preparation and
Mathia, T.G. +5 more
core +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
The Effect of Surface Oil on Ocean Wind Stress
Earth, 2023 This study provides, to the best of our knowledge, the first detailed analysis of how surface oil modifies air–sea interactions in a two-way coupled model, i.e., the coupled–ocean–atmosphere–wave–sediment–transport (COAWST) model, modified to account for
Daneisha Blair +2 more
doaj +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source
Quantifying subglacial roughness and its link to glacial geomorphology and ice speed [PDF]
, 2013 The shape of subglacial bed topography, termed its roughness, is a recognised control on basal ice-flow. Although glaciologists have observed patterns of variations in ice speed over beds with different roughness values, the strength of this relationship
PRESCOTT, PHILIP,WILLIAM
core
Advanced Engineering Materials, EarlyView.Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt +8 more
wiley +1 more source
Bridge roughness index as an indicator of bridge dynamic amplification [PDF]
, 2006 The concept of a road roughness index for bridge dynamics is developed. The International Roughness Index (IRI) is shown to be very poorly correlated with bridge dynamic amplification as it takes no account of the location of individual road surface ...
O'Brien, Eugene J. +2 more
core +1 more source
A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions
Advanced Engineering Materials, EarlyView.This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice +2 more
wiley +1 more source
Variations in sea surface roughness induced by the 2004 Sumatra-Andaman tsunami [PDF]
Natural Hazards and Earth System Sciences, 2009 Observations of tsunamis away from shore are critically important for improving early warning systems and understanding of tsunami generation and propagation. Tsunamis are difficult to detect and measure in the open ocean because the wave amplitude there
O. A. Godin +4 more
doaj