Results 101 to 110 of about 526,957 (346)

New organic-walled dinoflagellate cysts from recent sediments of central Asian seas [PDF]

open access: yes, 2004
Recent to sub-recent sediments from the Caspian Sea, the Kara-Bogaz-Gol Bay, the Enseli lake and the Aral Sea contain the new organic-walled dinoflagellate cysts Caspidinium, Caspidinium rugosum and Impagidinium caspienense.
Chalié, F   +3 more
core   +1 more source

Using Saildrones to Validate Satellite-Derived Sea Surface Salinity and Sea Surface Temperature along the California/Baja Coast

open access: yesRemote Sensing, 2019
Traditional ways of validating satellite-derived sea surface temperature (SST) and sea surface salinity (SSS) products by comparing with buoy measurements, do not allow for evaluating the impact of mesoscale-to-submesoscale variability.
J. Vazquez-Cuervo   +6 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Surface salinity of the North Atlantic : can we reconstruct its fluctuations over the last one hundred years ? [PDF]

open access: yes, 1994
Surface samples have been collected in the North Atlantic in the past one hundred years for determining the ocean salinity and its temperature. A large share of the data we have used were collected by merchant vessels of weather ships of European ...
Cayan, D.   +6 more
core   +1 more source

The Potential and Challenges of Using Soil Moisture Active Passive (SMAP) Sea Surface Salinity to Monitor Arctic Ocean Freshwater Changes

open access: yesRemote Sensing, 2018
Sea surface salinity (SSS) links various components of the Arctic freshwater system. SSS responds to freshwater inputs from river discharge, sea ice change, precipitation and evaporation, and oceanic transport through the open straits of the Pacific and ...
W. Tang   +7 more
semanticscholar   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

North Atlantic subpolar gyre along predetermined ship tracks since 1993: a monthly data set of surface temperature, salinity, and density [PDF]

open access: yesEarth System Science Data, 2018
We present a binned product of sea surface temperature, sea surface salinity, and sea surface density data in the North Atlantic subpolar gyre from 1993 to 2017 that resolves seasonal variability along specific ship routes (https://doi.org/10.6096/SSS-
G. Reverdin   +9 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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