Results 81 to 90 of about 526,957 (346)
Changing Salinity Gradients in the Baltic Sea As a Consequence of Altered Freshwater Budgets
Geophysical Research Letters, 2019 Climate change is expected to enhance the hydrological cycle in northern latitudes reducing the salinity in the Baltic Sea, a land‐locked marginal sea with a large catchment area located in northern Europe.
Madline Kniebusch +2 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Journal of Marine Science and EngineeringThe lack of dimensionality of ocean observations makes it difficult to utilize multi-scale data assimilation to correct model errors with limited observations.
Yueqi Zhao, Zhongjie He, Yuhang Jiang
doaj +1 more source
The last interglacial in the northern North Atlantic and adjacent areas: evidence for a more zonal climate than during the Holocene [PDF]
, 2011 We document climate conditions from the last interglacial optimum (LIO) or marine isotope stage 5e (MIS 5e) from terrestrial and oceanic sedimentary archives.
Bauch, Henning A. +5 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Scientia Marina, 2011 We study the interannual and seasonal variability in the Mediterranean Sea over the period 1958-2004 by comparing a numerical simulation (the 1/4º ORCA-R025 G70 model run, ‘ORCA’ hereafter) with altimetry and the MEDAR temperature and salinity database ...
Enrique Vidal-Vijande +4 more
doaj +1 more source
ARCTIC SEA SURFACE SALINITY RETRIEVAL FROM SMOS MEASURES
, 2019 IEEE International Geoscience and Remote Sensing Symposium (IGARSS 2019), 28 July - 2 August 2019, Yokohama, Japan.- 1 page ...
Martínez, Justino +14 more
openaire +3 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Evaporation induced convection enhances mixing in the upper ocean
Frontiers in Marine Science, 2023 The upper ocean surface layer is directly affected by the air-sea fluxes. The diurnal variations in these fluxes also cause the upper ocean mixed layer turbulence and mixing to diurnally vary. The underlying thermohaline structure also varies accordingly
Devang Falor +5 more
doaj +1 more source
On the calculation of air-sea fluxes of CO2 in the presence of temperature and salinity gradients [PDF]
, 2016 The presence of vertical temperature and salinity gradients in the upper ocean and the occur- rence of variations in temperature and salinity on time scales from hours to many years complicate the calculation of the flux of carbon dioxide (CO2) across ...
Donlon, CJ +4 more
core +1 more source