Results 101 to 110 of about 802,355 (333)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Climate dynamics experiments using a GCM simulations [PDF]

The study of surface-atmosphere interactions has begun with studies of the effect of altering the ocean and land boundaries. A ten year simulation of global climate using observed sea surface temperature anomalies has begun using the NCAR Community ...
Christy, John R., Fitzjarrald, Dan, Lu, H.-I., Robertson, Franklin R., Sohn, B., Srikishen, J.   +5 more
core   +1 more source

CAVIAR: Climate variability of the Baltic Sea area and the response of the general circulation of the Baltic Sea to climate variability [PDF]

, 2010
The warming trend for the entire globe (1850-2005) is 0.04°C per decade. A specific warming period started around 1980 and continues at least until 2005, with a temperature increase of about 0.17°C per decade.
Getzlaff, Klaus, Hinrichsen, Hans-Harald, Köster, F., Lehmann, Andreas   +3 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Relative importance of meridional and zonal sea surface temperature gradients for the onset of the ice ages and Pliocene-Pleistocene climate evolution

, 2022
Chris, Alexey
openalex   +1 more source

Atmospheric response to variations in sea surface temperature [PDF]

An extended range prediction experiment was performed with the GISS atmospheric model on a global data to test the sensitivity of the model to sea surface temperature (SST) variation over a two-week forecast period.
Atlas, R., Spar, J.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Remotly Sensed Sea Surface Temperature from Aircraft

Gayana, 2004
The experiment was conducted around south of the Azores islands, in the middle eastern part of the northern-Atlantic basin. The experimental area was situated between 31°N-38°N and 21°W-28°W. The experiment was performed in order to improve our knowledge
B. H. Kwon, B. Benech, P. Durand, Y. S. Kim   +3 more
doaj  

Seasonal Variability of Wind, Surface Current and Sea Surface Temperature in the Eastern Seram Waters During the 2015 Super El Nino

Nekton
The eastern Seram waters are influenced by both the Seram Sea and the Banda Sea. This study aimed to examine variations in wind, surface currents, and sea surface temperature (SST) during 2015, coinciding with the super El Niño event.
Cipta Utama, Simon Tubalawony, Harold Joppie Davido Waas, Ronald Darlly Hukubun, Marlin Chrisye Wattimena   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source