Results 91 to 100 of about 5,985 (143)

Pro‐ and anti‐inflammatory cytokines mediate the progression of severe anemia in malaria‐infected children: A prospective study

Immunity, Inflammation and Disease, Volume 12, Issue 9, September 2024.
Abstract Background Severe Plasmodium falciparum malarial anemia is still the principal cause of death in children in underdeveloped countries. An imbalance between proinflammatory and anti‐inflammatory cytokines is associated with malaria progression.
Charles Nkansah, Felix Osei‐Boakye, Gabriel Abbam, Samuel K. Appiah, Samira Daud, Bright Boakye, Samsiyatu Abdulai, Madina Ahmed, Theophilus B. Antwi, Birago Boateng, Miigbat P. Libatin, Alexander S. Mensah, Mary K. Missah, Richard V. Duneeh, Ashiya Haruna, Stephany Adda, Pagnaa G. Abdul‐Rauf, Zacharia A. Ofori, George B. Fosu, Sandra Segnitome, Isaac Adjei, Emmanuel Appiah‐Kubi, Moses Banyeh, Charles A. Derigubah, Muniru M. Tanko, Ejike F. Chukwurah   +25 more
wiley   +1 more source

Prevalence of molecular markers of drug resistance in an area of seasonal malaria chemoprevention in children in Senegal [PDF]

Malaria Journal, 2013
In sub-Saharan Africa, malaria is the leading cause of morbidity and mortality especially in children. In Senegal, seasonal malaria chemoprevention (SMC) previously referred to as intermittent preventive treatment in children (IPTc) is a new strategy for malaria control in areas of high seasonal transmission.
Lo, A. C., Faye, B., Ba, E. H., Cisse, B., Tine, R., Abiola, A., Ndiaye, M., Ndiaye, J. L. A., Ndiaye, D., /Sokhna, Cheikh, Gomis, J. F., Dieng, Y., Faye, O., Ndir, O., Milligan, P., Cairns, M., Hallett, R., Sutherland, C., Gaye, O.   +18 more
openaire   +5 more sources

Lingering challenges in malaria elimination efforts in sub‐Saharan Africa: Insights and potential solutions

Health Science Reports, Volume 7, Issue 6, June 2024.
Abstract Introduction Between 2000 and 2015, significant gains were recorded in reducing the global burden of malaria due to enhanced global collaboration and increased funding. However, progress has stagnated post‐2015, and the COVID‐19 pandemic seems to have reversed some of these gains, necessitating a critical reevaluation of interventions.
Lukman Lawal, Ahmad Oyindamola Buhari, Tawakalitu Abdulateef Jaji, Abdulrahman Salaudeen Alatare, Abdulmalik Opeyemi Adeyemo, Aishat Oluwakemi Olumoh, Yusuff Adesoji Yusuff, Gabriel Osborn, Abdulazeez Biodun Mogaji, Bello Hussein Adoto, Nafisa Gbemisola Ibrahim, Waliyullahi Oluwafemi Saliu, Toufik Abdul‐Rahman   +12 more
wiley   +1 more source

The use of formative research to inform the design of a seasonal malaria chemoprevention intervention in northern Nigeria [PDF]

Malaria Journal, 2016
Experience of seasonal malaria chemoprevention (SMC) is growing in the Sahel sub-region of Africa, though there remains insufficient evidence to recommend a standard deployment strategy. In 2012, a project was initiated in Katsina state, northern Nigeria, to design an appropriate and effective community-based delivery approach for SMC, in consultation ...
Madeleine Marasciulo, Sandrine Martin, Musa Abubakar Kana, Musa Abubakar Kana, Musa Abubakar Kana, Maxwell Kolawole, Ebenezer Baba, Prudence Hamade, John Dada, Naome Wandera, Sylvia Meek, Tanimu Babale, Clare E. Strachan, Clare E. Strachan, Helen Counihan   +14 more
openaire   +4 more sources

Medication adherence framework: A population‐based pharmacokinetic approach and its application in antimalarial treatment assessments

CPT: Pharmacometrics &Systems Pharmacology, Volume 13, Issue 5, Page 795-811, May 2024.
Abstract We reported here on the development of a pharmacometric framework to assess patient adherence, by using two population‐based approaches – the percentile and the Bayesian method. Three different dosing strategies were investigated in patients prescribed a total of three doses; (1) non‐observed therapy, (2) directly observed administration of ...
Junjie Ding, Richard M. Hoglund, Joel Tarning   +2 more
wiley   +1 more source

Evidence that seasonal malaria chemoprevention with SPAQ influences blood and pre-erythrocytic stage antibody responses of Plasmodium falciparum infections in Niger [PDF]

, 2021
Lamine Mahaman Moustapha, Rafiou Adamou, Maman Laminou Ibrahim, Mariama Abdoulaye Louis Padounou, Abdoulaye Diallo, David Courtin, Jean Testa, Jean Louis Ndiaye   +7 more
openalex   +1 more source

Seasonal Malaria Chemoprevention Coverage Survey Guinea, 2018

, 2019
The 2018 SMC coverage survey in Guinea was conducted by the University Gamal Abdel Nasser, Conakry and the London School of Hygiene & Tropical Medicine, in collaboration with the National Malaria Control Programme and Catholic Relief Services ...
Loua, Kovana Marcel, Milligan, Paul
openaire   +2 more sources

Estimation of trajectory of protective efficacy in infectious disease prevention trials using recurrent event times

Statistics in Medicine, Volume 43, Issue 9, Page 1759-1773, 30 April 2024.
In studies of infectious disease prevention, the level of protective efficacy of medicinal products such as vaccines and prophylactic drugs tends to vary over time. Many products require administration of multiple doses at scheduled times, as opposed to one‐off or continual intervention. Accurate information on the trajectory of the level of protective
Yin Bun Cheung, Xiangmei Ma, K. F. Lam, Chee Fu Yung, Paul Milligan   +4 more
wiley   +1 more source

Randomized, placebo‐controlled, double‐blind phase I trial of co‐administered pyronaridine and piperaquine in healthy adults of sub‐Saharan origin

Clinical and Translational Science, Volume 17, Issue 4, April 2024.
Abstract Drug resistance to sulfadoxine‐pyrimethamine and amodiaquine threatens the efficacy of malaria chemoprevention interventions in children and pregnant women. Combining pyronaridine (PYR) and piperaquine (PQP), both components of approved antimalarial therapies, has the potential to protect vulnerable populations from severe malaria.
Andrea Kuemmerle, Denis Gossen, Annick Janin, Andrew Stokes, Nada Abla, Maja Szramowska, Ulrike Lorch, Myriam El Gaaloul, Isabelle Borghini‐Fuhrer, Stephan Chalon   +9 more
wiley   +1 more source

Assessment of the Feasibility, Acceptability, and Impact of Implementing Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study (Preprint) [PDF]

, 2021
Alexandra Wharton–Smith, K. Scott Baker, Arantxa Roca‐Feltrer, Maria Rodrigues, Sol Richardson, Craig Bonnington, Christian Rassi, Madeleine Marasciulo, Sónia Enosse, Francisco Saúte, Pedro Aíde, Eusébio Macete, Baltazar Candrinho   +12 more
openalex   +1 more source