Results 51 to 60 of about 34,551 (199)

Anticancer Activities of Meroterpenoids Isolated from the Brown Alga Cystoseira usneoides against the Human Colon Cancer Cells HT-29 [PDF]

, 2020
Colorectal cancer (CRC) is one of the most common types of cancers and a leading cause of cancer death worldwide. The current treatment for CRC mainly involves surgery, radiotherapy, and chemotherapy. However, due to the side effects and the emergence of
Calderón-Montaño, Jose M., Motilva, Virginia, Reyes Jiménez, Carolina de los, Zbakh, Hanaa, Zubía Mendoza, Eva   +4 more
core   +2 more sources

Interaction of Bacillus subtilis CsaA with SecA and precursor proteins [PDF]

Biochemical Journal, 2000
CsaA from the Gram-positive bacterium Bacillus subtilis has been identified previously as a suppressor of the growth and protein-export defect of Escherichia coli secA(Ts) mutants. CsaA has chaperone-like activities in vivo and in vitro. To examine the role of CsaA in protein export in B. subtilis, expression of the csaA gene was repressed.
Müller, Jörg P., Ozegowski, Jörg, Vettermann, Stefan, Swaving, Jelto, Wely, Karel H.M. van, Driessen, Arnold J.M.   +5 more
openaire   +3 more sources

The protein import apparatus of chloroplasts [PDF]

, 1993
Routing of cytosolically synthesized precursor proteins into chloroplasts is a specific process which involves a multitude of soluble and membrane components.
Bartling D., Bassham D. C., Buvinger W. E., Cline K., Cline K., Cline K., Heike Alefsen, Joyard J., Jürgen Soll, Kirwin P. M., Li H.‐M., Mould R. M., Olsen L. J., Olsen L. J., Perry S. E., Pilon M., Schnell D. J., Theg S. M.   +17 more
core   +1 more source

Novel Sequence Feature of SecA Translocase Protein Unique to the Thermophilic Bacteria: Bioinformatics Analyses to Investigate Their Potential Roles

Microorganisms, 2019
SecA is an evolutionarily conserved protein that plays an indispensable role in the secretion of proteins across the bacterial cell membrane. Comparative analyses of SecA homologs have identified two large conserved signature inserts (CSIs) that are ...
Bijendra Khadka, Dhillon Persaud, Radhey S. Gupta   +2 more
doaj   +1 more source

A genetic approach to study the relationship between maternal Vitamin D status and newborn anthropometry measurements: the Vitamin D pregnant mother (VDPM) cohort study [PDF]

, 2020
Purpose Adverse effects of maternal vitamin D deficiency have been linked to adverse pregnancy outcomes. We investigated the relationship between maternal vitamin D status and newborn anthropometry measurements using a genetic approach and examined the ...
Aji, Arif Sabta, Alathari, Buthaina, Erwinda, Erwinda, Lipoeto, Nur Indrawaty, Lovegrove, Julie Anne, Malik, Safarina G., Rasyid, Rosfita, Vimaleswaran, Karani Santhanakrishnan, Yusrawati, Yusrawati   +8 more
core   +1 more source

Escherichia coli Can Adapt Its Protein Translocation Machinery for Enhanced Periplasmic Recombinant Protein Production

Frontiers in Bioengineering and Biotechnology, 2020
Recently, we engineered a tunable rhamnose promoter-based setup for the production of recombinant proteins in E. coli. This setup enabled us to show that being able to precisely set the production rate of a secretory recombinant protein is critical to ...
Alexandros Karyolaimos, Katarzyna Magdalena Dolata, Minia Antelo-Varela, Anna Mestre Borras, Rageia Elfageih, Susanne Sievers, Dörte Becher, Katharina Riedel, Jan-Willem de Gier   +8 more
doaj   +1 more source

SecA Cotranslationally Interacts with Nascent Substrate Proteins In Vivo

Journal of Bacteriology, 2017
ABSTRACT SecA is an essential component of the Sec machinery in bacteria, which is responsible for transporting proteins across the cytoplasmic membrane. Recent work from our laboratory indicates that SecA binds to ribosomes.
Damon Huber, Mohammed Jamshad, Ruby Hanmer, Daniela Schibich, Kristina Döring, Isabella Marcomini, Günter Kramer, Bernd Bukau   +7 more
openaire   +2 more sources

Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold [PDF]

, 2019
The virtual screening of a library of chalcone derivatives led us to the identification of potential new MDM2 ligands. The chalcones with the best docking scores obeying the Lipinski rule of five were subsequently prepared by base-catalyzed aldol ...
Cidade, Honorina, Gomes, Sara, Helena Vasconcelos, M., Lima, Raquel T., Maciel, Claudia, Palmeira, Andreia, Pereira, Daniela, Pinto, Madalena, Raimundo, Liliana, Saraiva, Lucília, Seca, Hugo, Soares, Joana, Sousa, Emília   +12 more
core   +3 more sources

Roles of SecG in ATP- and SecA-dependent protein translocation [PDF]

Proceedings of the National Academy of Sciences, 1998
SecA, the translocation ATPase in Escherichia coli , undergoes cycles of conformational changes (insertion/deinsertion) in response to ATP and a preprotein. The membrane-embedded portion of protein translocase, SecYEG, has crucial roles in the SecA-driven preprotein translocation reaction. We previously identified a
G, Matsumoto, H, Mori, K, Ito
openaire   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source