Results 1 to 10 of about 559 (86)

Uncovering the Mechanism of Azepino-Indole Skeleton Formation via Pictet-Spengler Reaction by Strictosidine Synthase: A Quantum Chemical Investigation. [PDF]

ChemistryOpen, 2023
The detailed reaction mechanism of the Pictet–Spengler condensation of 1H‐indol‐4‐ethanamine with secologanin by strictosidine synthase was revealed by quantum chemical cluster calculations. Abstract Strictosidine synthase (STR) catalyzes the Pictet–Spengler (PS) reaction of tryptamine and secologanin to produce strictosidine.
Mou M, Zhang C, Zhang S, Chen F, Su H, Sheng X.   +5 more
europepmc   +2 more sources

A Systematic Review of Analytical Methods for Quantification of Natural Indole Alkaloids from Catharanthus and Rauvolfia Species [PDF]

Research Journal of Pharmacognosy, 2023
Indole alkaloids are a class of alkaloids enclosing a structural moiety of indole; numerous indole alkaloids also comprise isoprene groups and are thus named terpene indole or secologanin tryptamine alkaloids and have more than 4100 identified diverse ...
Lakshmipriya Murugesan, Kokilambigai Shanmugaramasamy*, Ilango Kaliappan   +2 more
doaj   +1 more source

Improved protein glycosylation enabled heterologous biosynthesis of monoterpenoid indole alkaloids and their unnatural derivatives in yeast

Metabolic Engineering Communications, 2023
With over 3000 reported structures, monoterpenoid indole alkaloids (MIAs) constitute one of the largest alkaloid groups in nature, including the clinically important anticancer drug vinblastine and its semi-synthetic derivatives from Catharanthus roseus (
Mohammadamin Shahsavarani, Joseph Christian Utomo, Rahul Kumar, Melina Paz-Galeano, Jorge Jonathan Oswaldo Garza-García, Zhan Mai, Dae-Kyun Ro, Yang Qu   +7 more
doaj   +1 more source

Rigorous Biogenetic Network for a Group of Indole Alkaloids Derived from Strictosidine

Molecules, 2008
: Strictosidine, the precursor of more than 2,500 indole alkaloids, was isolated from four species of three plant families. By searching the Dictionary of Natural Products on DVD it was found that about 150 indole alkaloids were obtained from the same ...
László F. Szabó
doaj   +1 more source

Ipecac alkaloid biosynthesis in two evolutionarily distant plants. [PDF]

Nat Chem Biol
Colinas M, Morweiser C, Dittberner O, Chioca B, Alam R, Leucke H, Nakamura Y, Serna Guerrero DA, Heinicke S, Kunert M, Wurlitzer J, Ploss K, Hong B, Grabe V, Lopes AA, O'Connor SE.   +15 more
europepmc   +1 more source

Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast. [PDF]

Nat Chem Biol, 2023
Bradley SA, Lehka BJ, Hansson FG, Adhikari KB, Rago D, Rubaszka P, Haidar AK, Chen L, Hansen LG, Gudich O, Giannakou K, Lengger B, Gill RT, Nakamura Y, de Bernonville TD, Koudounas K, Romero-Suarez D, Ding L, Qiao Y, Frimurer TM, Petersen AA, Besseau S, Kumar S, Gautron N, Melin C, Marc J, Jeanneau R, O'Connor SE, Courdavault V, Keasling JD, Zhang J, Jensen MK.   +31 more
europepmc   +1 more source

Enzymatic epimerization of monoterpene indole alkaloids in kratom. [PDF]

Nat Chem Biol
McDonald A, Nakamura Y, Schotte C, Titchiner G, Lau K, Alam R, Lopes AA, Buell CR, O'Connor SE.   +8 more
europepmc   +1 more source

Evaluation of the expression pattern of TIAs pathway genes in response to tryptophan amino acid treatment and drought stress in Catharanthus roseus. [PDF]

PLoS One
Yousefi F, Mashhadi AA, Lotfi Jalal Abadi A, Shafeinia A, Jalily S, Soltani N.   +5 more
europepmc   +1 more source

Development of an efficient Agrobacterium-mediated transformation method and its application in tryptophan pathway modification in Catharanthus roseus. [PDF]

Plant Biotechnol (Tokyo), 2023
Kisaka H, Chin DP, Miwa T, Hirano H, Uchiyama S, Mii M, Iyo M.   +6 more
europepmc   +1 more source

Metabolic profiling and pharmacological evaluation of alkaloids in three <i>Murraya</i> species. [PDF]

Front Plant Sci
Huang H, Geng X, Wang L, Wang X, Liu F, Peng Y, Tang C, Chen R, Liu Q.   +8 more
europepmc   +1 more source