Results 51 to 60 of about 97,166 (237)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Nuclear Materials and Energy, 2017 By application of a horizontal magnetic field, BH, with 0.3% against a toroidal magnetic field, BT, electron cyclotron wall conditioning (ECWC) plasmas produced by 2nd-harmonic X-mode (X2-mode) EC waves expand radially toward the inner wall, which is to ...
Masakatsu Fukumoto +5 more
doaj +1 more source
SECOND ORDER OPTIMALITY CONDITIONS
Doklady Belorusskogo gosudarstvennogo universiteta informatiki i radioèlektroniki, 2019 Nonlinear programming problems are studied. Necessary second order optimality conditions are proved under minimal assumptions about constraints.
A. E. Leschov, L. I. Minchenko
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Roles of aminergic neurons in formation and recall of associative memory in crickets
Frontiers in Behavioral Neuroscience, 2010 We review recent progress in the study of roles of octopaminergic (OA-ergic) and dopaminergic (DA-ergic) signaling in insect classical conditioning, focusing on our studies on crickets.
Makoto Mizunami, Yukihisa Matsumoto
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
'Man is the Measure of All Things'
Footprint, 2019 The term Man, and the humanist tradition which followed from it, have been challenged in feminist, queer, poststructuralist, and postcolonial critiques, which questioned its nature, or even pondered if we are actually human. What we seek in this issue of
Victor Muñoz Sanz, Dan Handel
doaj +1 more source