Results 61 to 70 of about 2,352,988 (278)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Non-fatal disease burden for subtypes of depressive disorder: population-based epidemiological study [PDF]

, 2016
Background: Major depression is the leading cause of non-fatal disease burden. Because major depression is not a homogeneous condition, this study estimated the non-fatal disease burden for mild, moderate and severe depression in both single episode and ...
AC Leon, AJ Ferrari, Anneke van Schaik, BM Craig, C Murray, CBS Statistics Netherlands, CD Mathers, CJ Murray, Claudi L.H. Bockting, E Bromet, Filip Smit, G Andrews, G Andrews, Gemma D. Kok, Harm W.J. van Marwijk, Henriette E. van der Horst, HU Wittchen, J Alonso, J Brazier, J Neumann Von, J Spijker, JA Salomon, JE Ware, JE Ware Jr, JM Haro, Karolien E.M. Biesheuvel-Leliefeld, M Baker, M Have Ten, M Knight, M Locadia, Margreet ten Have, ME Kruijshaar, National Center for Vital and Health Statistics, P Cuijpers, P Dolan, R Graaf de, R Graaf de, R Graaf de, RC Kessler, RC Kessler, RC Kessler, Ron de Graaf, RV Bijl, SI Saarni, T Vos, T Vos, WE Broadhead, World Health Organization, X Badia   +48 more
core   +4 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Harboring alien lifeworlds: The second-person in thought insertion

Cuadernos de Filosofía Latinoamericana
In phenomenology, the delusion of thought insertion is described and explained in different ways. There is a common idea that the delusion depends either on a lack of sense of agency or on a confusion between self and others. I propose that the delusion
María Clara Garavito
doaj   +1 more source

First-Person Video Modeling as a Way of Teaching Imitation of Children with Autism [PDF]

Клиническая и специальная психология, 2018
The article discusses the problem of the basic factors of ASD: the deficit in the Theory of Mind (ToM) as the ability to represent Self-Other relationship, or violation of the ability to simulate, as the ability to transfer the perspective of Other’s ...
Novgorodtseva A., Yakovleva N.
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Sickness in Storytelling: The Effects of Chronic Illness on Memoir and the Author [PDF]

, 2019
The thesis will be in two parts, research and creative. The first part will be a research-based paper exploring how the creation and content of memoir is influenced by authors with chronic illness, and the difficulties and unique perspective these ...
Jackson, Sarah
core   +1 more source

The Structure of Episodic Memory: Ganeri's ‘Mental Time Travel and Attention’ [PDF]

, 2017
We offer a framework for assessing what the structure of episodic memory might be, if one accepts the Buddhist denial of persisting selves. This paper is a response to Jonardon Ganeri's paper "Mental time travel and attention", which explores Buddhaghosa'
Siegel, Susanna, Silins, Nicholas
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source