Results 51 to 60 of about 297,617 (273)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

H-ABC tubulinopathy revealed by label-free second harmonic generation microscopy

Scientific Reports, 2022
Hypomyelination with atrophy of the basal ganglia and cerebellum is a recently described tubulinopathy caused by a mutation in the tubulin beta 4a isoform, expressed in oligodendrocytes.
Milvia Alata, Valeria Piazza, Carla Jaramillo-Restrepo, Jose R. Eguibar, Carmen Cortes, Victor H. Hernandez   +5 more
doaj   +1 more source

Optical second harmonic generation probe of two-dimensional ferroelectricity [PDF]

, 1999
Optical second harmonic generation (SHG) is used as a noninvasive probe of two-dimensional (2D) ferroelectricity in Langmuir-Blodgett (LB) films of copolymer vinylidene fluoride with trifluorethylene.
Aktsipetrov, Ashwell, Bune, Ducharme, L. M. Blinov, Legrand, Lüpke, Mermin, Mishina, O. A. Aktsipetrov, Pomerantz, Roberts, S. P. Palto, T. V. Misuryaev, T. V. Murzina, V. M. Fridkin, Weller   +16 more
core   +2 more sources

X-Ray Second Harmonic Generation

Physical Review Letters, 2014
We report clear experimental evidence for second harmonic generation at hard x-ray wavelengths. Using a 1.7 Å pumping beam generated by a free electron laser, we observe second harmonic generation in diamond. The generated second harmonic is of order 10 times the background radiation, scales quadratically with pump pulse energy, and is generated over a
Shwartz, S., Fuchs, M., Hastings, J. B., Inubushi, Y., Ishikawa, T., Katayama, T., Reis, D. A., Sato, T., Tono, K., Yabashi, M., Yudovich, S., Harris, S. E.   +11 more
openaire   +3 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Optical Second Harmonic Generation of Low-Dimensional Semiconductor Materials

Nanomaterials
In recent years, the phenomenon of optical second harmonic generation (SHG) has attracted significant attention as a pivotal nonlinear optical effect in research. Notably, in low-dimensional materials (LDMs), SHG detection has become an instrumental tool
Yue Fu, Zhengyan Liu, Song Yue, Kunpeng Zhang, Ran Wang, Zichen Zhang   +5 more
doaj   +1 more source

Ultrabroadband Optical Phenomena in Quadratic Nonlinear Media

IEEE Photonics Journal, 2010
We present a comprehensive framework to study the nonlinear evolution of ultrabroadband optical pulses in quadratic nonlinear media. We employ a nonlinear envelope equation that goes beyond the traditional slowly varying approximation and allows ...
M. Conforti, F. Baronio, C. De Angelis
doaj   +1 more source

Gurevich-Zybin system

, 2005
We present three different linearizable extensions of the Gurevich-Zybin system. Their general solutions are found by reciprocal transformations. In this paper we rewrite the Gurevich-Zybin system as a Monge-Ampere equation.
Alber S I, Antonowitz M, Bass F G, Benney D J, Borisov A B, Calogero F, Donato A, Dubrovin B A, Fairlie D B, Gurevich A V, Jaulent M, Jeans J H, Kamchatnov A M, Kaup D J, Kaup D J, Maxim V Pavlov, Nutku Y, Nutku Y, Olver P, Pavlov M V, Pavlov M V, Rogers C, Sagdeev R Z, Zeldovich Ya B   +23 more
core   +1 more source

Nonlinear-optical frequency-doubling meta-reflector: pulsed regime [PDF]

, 2015
The properties of backward-wave second harmonic meta-reflector operating in pulse regime are investigated. We show that ratio of the income pulse length to the thickness of the metaslab determines its important operational properties which are in ...
Myslivets, Sergey A., Popov, Alexander K.   +1 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source