Results 61 to 70 of about 63,654 (313)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

SECOND HARMONIC GENERATION IN NANOSTRUCTURED METAMATERIALS [PDF]

open access: yes, 2022
"We conduct a theoretical and numerical study on the second-harmonic (SH) optical response of nanostructured metamaterials. Metamaterials are composed of a periodic array of metallic or dielectric inclusions.
Ulises Ramírez
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Boosting and Taming Wave Breakup in Second Harmonic Generation

open access: yesFrontiers in Physics, 2021
Modulation instability is a universal phenomenon that can be found in a wide variety of nonlinear systems where, in the presence of a noise seed, peaks of random intensities can be generated. Several dynamical systems admit exact solutions in the form of
Raphaël Jauberteau   +10 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Quadrupole second harmonic generation and sum-frequency generation in ZnO quantum dots

open access: yesAIP Advances, 2015
The second harmonic generation (SHG) and the sum frequency generation (SFG) processes are investigated in the conduction band states of the singly charged ZnO quantum dot (QD) embedded in the HfO2, and the AlN matrices.
Deepti Maikhuri   +2 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

open access: yesFEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Second-harmonic generation tuning by stretching arrays of GaAs nanowires

open access: yes, 2022
We present a wearable device with III-V nanowires in a flexible polymer, which is used for active mechanical tuning of the second-harmonic generation intensity.
Kristina Frizyuk (6192026)   +9 more
core   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

X waves generated at the second harmonic [PDF]

open access: yesOptics Letters, 2003
The process of optical frequency doubling in the undepleted regime can lead to the generation of an X-wave envelope with group velocity locked to the pump beam. Its parameters and its angular spectrum are directly related to the zeroth- and first-order dispersive features of the nonlinear process.
CONTI, CLAUDIO, Stefano Trillo
openaire   +2 more sources

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