Results 61 to 70 of about 4,898,023 (356)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Second Language Acquisition

open access: yes, 2001
In the course of language acquisition, the learner passes through a series of ‘learner varieties,’ which approach successively the linguistic system of the learner's social environment. Children normally succeed in a perfect replication of this system.
openaire   +2 more sources

The relationship between first and second language composition writing [PDF]

open access: yes, 2007
This paper explores the ways in which the transfer of assumptions from L1 writing can sometimes help the process of writing in L2. In learning a second language writing skill,learners have two primary sources to construct a second language system ...
Ahangari, Saeideh
core  

English Assistant : a support strategy for online second language learning [PDF]

open access: yes, 2001
This paper presents an approach to the provision of on-line assistance for learners of English as a second language. The basis for this design is the application of directed support in the form of 'dynamic annotation' to English information.
Lepouras, G., Weir, G.R.S.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Pre-service CFL teachers’ conceptions of and attitudes toward ICT and image-GAI in Chinese teaching: A drawing perspective

open access: yesEducational Technology & Society
This study aimed to determine the perceptions and attitudes of preservice teachers of Chinese as a foreign language (CFL) toward applying information and computer technology (ICT) and image-generative artificial intelligence (image-GAI) tools in CFL ...
Yu-Ju Lan, Yi-Hsuan Chen, Yun-Fang Tu
doaj   +1 more source

Collaborative Writing in L2 Classrooms

open access: yesWorking Papers in Applied Linguistics and TESOL, 2015
With the appearance and improvement of Web 2.0 technology and other digital tools such as Google Docs and wikis, teachers and researchers are increasingly able to implement collaborative activities in face-to-face and online language courses.
Dennis Koyama
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

On Some Features of Logical Thought in Writing

open access: yesArmenian Folia Anglistika, 2016
This paper considers some features of logical thinking in persuasive essay writing. A solid essay is logically organized and well-developed; it advances consistent arguments supported by strong evidence.
Marina Karapetyan
doaj   +1 more source

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