Results 71 to 80 of about 10,492,879 (293)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Issues in Teaching Second Language Reading [PDF]

, 1998
Look through the window of any second or foreign language (L2) reading classroom and, invariably, you will see teacher and students seated with books open in front of them.
Bamford, Julian, Day, Richard R.
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

On Some Features of Logical Thought in Writing

Armenian Folia Anglistika, 2016
This paper considers some features of logical thinking in persuasive essay writing. A solid essay is logically organized and well-developed; it advances consistent arguments supported by strong evidence.
Marina Karapetyan
doaj   +1 more source

Mnemotechnics in second-language learning.

American Psychologist, 1975
For some time I have been involved in efforts to develop computer-controlled systems for instruction. One such effort has been a computer-assistedinstruction (CAI) program for teaching reading in the primary grades (Atkinson, 1974) and another for teaching computer science at the college level (Atkinson, in press).
openaire   +4 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Functional Discourse Units for Second Language Research

, 1988
DISCOURSE ANALYSIS has been an accepted part of the methodology of second language (SL) research for some time (see, e.g., Chaudron, 1988, pp. 40-45; Hatch, 1978; Hatch & Long, 1980; Larsen-Freeman, 1980), and its procedures are becoming increasingly ...
Crookes, Graham
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Introducing Second Language Assessment

Studies in Applied Linguistics & TESOL
Published by Cambridge University Press in 2025, Introducing Second Language Assessment by Gary J. Ockey, Professor of Applied Linguistics at Iowa State University, is a recent addition to the field of second language (L2) assessment.
Zarin Tasnim
doaj   +1 more source

Second Language Acquisition

, 2001
In the course of language acquisition, the learner passes through a series of ‘learner varieties,’ which approach successively the linguistic system of the learner's social environment. Children normally succeed in a perfect replication of this system.
openaire   +2 more sources