Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Psychophysiological factors as predictors of second language writing achievement in a computer-based test. [PDF]
Front Psychol, 2022 Lee SP, Chang SL, Su HK, Cui ZY, Lee SD.
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
The Effect of Joint Production on the Accuracy and Complexity of Second Language Writing. [PDF]
J Psycholinguist Res, 2023 Sang Z, Zou W.
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
The Impact of Academic Procrastination on Second Language Writing: The Mediating Role of L2 Writing Anxiety. [PDF]
Front Psychol, 2022 Zhang C, Zhang W.
europepmc +1 more source
Developing Autonomous Self-Editors: An Alternative Approach to Written Corrective Feedback
The CATESOL Journal, 2019 Written corrective feedback has been a long-standing practice among second language writing instructors, yet the efficacy of this practice for long-term development of students’ writing remains uncertain. In th field of writing research, error correction
Undarmaa Maamuujav
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Models and the Knowledge Base of Second Language Teacher Education [PDF]
, 1993 Although teacher education programs have been in existence for a long time, second language teacher education is a relatively recent development. Traditionally, second or foreign language teachers were either native speakers of the target language or had
Day, Richard
core +1 more source
Dynamic development of syntactic complexity in second language writing: A longitudinal case study of a young Chinese EFL learner. [PDF]
Front Psychol, 2022 Wang Z.
europepmc +1 more source