Results 121 to 130 of about 19,188,680 (306)
Pooled estimates of factors associated with second-line HIV treatment failure.
, 2019 Pooled estimates of factors associated with second-line HIV treatment failure.
Mekonnen Sisay (5594804) +2 more
core +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
What is the best second‐line treatment for immune thrombocytopenia?
British Journal of HaematologyThe choice between thrombopoietin receptor agonists (TPO‐RAs) and anti‐CD20 as the preferred second‐line therapies for immune thrombocytopenia remains in the eye of the beholders. Each has major advantages and certain weaknesses. Stolz et al. describe a single‐centre experience that whets our appetite for a large randomized controlled trial comparing a
Matthieu Mahévas, James B. Bussel
openaire +2 more sources
Forest pilot of proportion for second-line HIV treatment failure in SSA.
, 2019 Forest pilot of proportion for second-line HIV treatment failure in SSA.
Mekonnen Sisay (5594804) +2 more
core +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
National Treatment Purchase Fund annual report 2004.
, 2004 The mission of the National Treatment Purchase Fund is to reduce the length of time public patients are on hospital waiting lists by offering them a choice in obtaining access to treatment quickly, safely and to a high standard of patient satisfaction ...
National Treatment Purchase Fund
core
Accumulation of Protease Mutations According to Duration of Second-Line Treatment Failure.
, 2013 Accumulation of Protease Mutations According to Duration of Second-Line Treatment Failure.
Godwin E. Imade (459674) +11 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
First line antiretroviral treatment failure and second line treatment outcomes among HIV patients in Southern Africa [PDF]
, 2016 Southern Africa has the highest prevalence of HIV worldwide, and South Africa has the highest number of HIV infected people. South Africa and other resource-limited countries provide antiretroviral therapy (ART) for people with HIV, with limited ...
Rohr, Julia Katherine
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source