Results 41 to 50 of about 19,188,680 (306)

Cholangiocarcinoma: the quest for a second-line systemic treatment

Translational Cancer Research, 2019
Biliary tract cancers (BTC) are a heterogeneous group of epithelial neoplasms, with a poor prognosis. Advanced BTC remains a challenging, non-curable disease. Gemcitabine plus platinum chemotherapy is the standard of care as first-line (L1) therapy in this setting. Beyond failure of L1, available evidence to guide therapeutic decisions is scarce.
Vienot, Angélique, Neuzillet, Cindy
openaire   +2 more sources

Combinations of second-line treatment.

, 2019
Combinations of second-line treatment.
Magdalena Piróg (6281519), Lubomir Bodnar (6281510), Dorota Babczyk (6281516), Tomasz Basta (6281501), Robert Jach (6281531), Anna Horbaczewska (6281528), Paweł Knapp (6281504), Iwona Gawron (6281513), Paweł Blecharz (6281507), Anna Markowska (6281525), Tomasz Kluz (6281522)   +10 more
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Second- and third-line treatment agents in autoimmune hepatitis (AIH): Where do we stand?

Exploration of Digestive Diseases
Autoimmune hepatitis (AIH) is a chronic liver disease of unknown aetiology that can lead to end stage liver disease if left without treatment. Corticosteroids with or without azathioprine (AZA) are considered the recommended standard first-line treatment
Pinelopi Arvaniti, Ignasi Olivas, Sergio Rodriguez-Tajes, George N. Dalekos, Maria-Carlota Londoño   +4 more
doaj   +1 more source

Time to switch from first-line to second-line treatment.

, 2018
Time to switch from first-line to second-line treatment.
Qiang Shi (191722), Chien-Hsun Lee (3753640), Ko-Jen Li (730660), Carol L. Gaich (5071301), Wesley Furnback (5071307), Tamas Treuer (5071304), Bruce C. M. Wang (5071313), Wen-Shuo Wu (5071310), Chao-Hsiun Tang (4242457)   +8 more
core   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Second line anti-cancer therapy for metastatic colorectal cancer: treatment strategy

Медицинский совет, 2015
Colorectal cancer is one of the most widespread cancers globally. Over the past decade, there has been a significant progress in the treatment of metastatic colorectal cancer.
K. A. Vorontsova, N. V. Dobrova, G. V. Vyshinskaya   +2 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Treatment failure and associated factors among first line patients on highly active antiretroviral therapy in Ethiopia: a systematic review and meta-analysis

Global Health Research and Policy, 2019
Background Antiretroviral therapy (ART) restores immune function and reduces human immunodeficiency virus (HIV) related adverse outcomes. The results of previous studies in Ethiopia were replete with inconsistent findings; nonexistence of national ...
Moges Agazhe Assemie, Muluneh Alene, Daniel Bekele Ketema, Selishi Mulatu   +3 more
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source