Second messenger system - Open Access .click

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Integrated Metabolomics and Proteomics Analysis Revealed Second Messenger System Disturbance in Hippocampus of Chronic Social Defeat Stress Rat [PDF]

Frontiers in Neuroscience, 2019
Depression is a common and disabling mental disorder characterized by high disability and mortality, but its physiopathology remains unclear. In this study, we combined a non-targeted gas chromatography-mass spectrometry (GC-MS)-based metabolomic ...
Li-Ning Yang +12 more
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The cyclic di-GMP receptor YcgR links the second messenger with the putrescine quorum sensing system in modulation of Dickeya oryzae motility [PDF]

mBio
Dickeya oryzae is a prevalent pathogen capable of infecting a variety of crops and plants, and its cell motility plays a key role in invasion of host and subsequent systemic infection. We recently demonstrated that the bacterial second messenger c-di-GMP
Weihan Gu +7 more
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Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger [PDF]

Nature Communications, 2021
Many bacterial cyclic-oligonucleotide-based antiphage signaling systems (CBASS) employ effectors with SAVED domains. Here, the authors present a biochemical and structural characterization of two such CBASS, providing mechanistic insights into bacterial ...
Shirin Fatma +3 more
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The Mycobacterium tuberculosis PhoPR virulence system regulates expression of the universal second messenger c-di-AMP and impacts vaccine safety and efficacy

Molecular Therapy: Nucleic Acids, 2022
Cyclic (di)nucleotides act as universal second messengers endogenously produced by several pathogens. Specifically, the roles of c-di-AMP in Mycobacterium tuberculosis immunity and virulence have been largely explored, although its contribution to the ...
Irene Pérez +9 more
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Second messenger systems and adaptation. [PDF]

Gut, 1987
Adaptive changes represent shifts in the equilibrium state of biologic systems in reponse to long standing alterations in their surrounding environment. Adaptation encompasses a variety of cellular changes ranging from very specific responses, such as variation in the production of a single protein, to broader responses including alterations in the ...
Fred S. Gorelick
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Adrenoceptors and Their Second Messenger Systems [PDF]