Results 21 to 30 of about 539,249 (323)

Glutamate induces autophagy via the two-pore channels in neural cells [PDF]

, 2016
NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2.
 , ,, Antonioli, M, Bincoletto, C, Fimia, G, Hirata, H, Nascimento, A, Pereira, G, Piacentini, M, Smaili, S, Ureshino, R, Vescovo, T   +11 more
core   +4 more sources

Second messenger systems in Tourette's syndrome

Journal of the Neurological Sciences, 1995
Abnormalities within second messenger systems have been hypothesized as the underlying pathophysiologic mechanism in a variety of neuropsychiatric disorders. In the Gilles de la Tourette syndrome (TS) prior studies have shown that the concentration of adenosine 3',5'-monophosphate (cAMP) is reduced in cortical and putamen brain regions.
H S, Singer, J, Dickson, D, Martinie, M, Levine   +3 more
openaire   +2 more sources

Intermingled cAMP, cGMP and calcium spatiotemporal dynamics in developing neuronal circuits

Frontiers in Cellular Neuroscience, 2014
cAMP critically modulates the development of neuronal connectivity. It is involved in a wide range of cellular processes that require independent regulation.
Stefania eAveraimo, Stefania eAveraimo, Stefania eAveraimo, Xavier eNicol, Xavier eNicol, Xavier eNicol   +5 more
doaj   +1 more source

Second Messenger Systems in Human Gliomas

Archives of Pathology & Laboratory Medicine, 2007
AbstractContext.—Patients with glioblastoma (astrocytoma, World Health Organization grade IV) exhibit 2-year survival rates of less than 20% despite significant advances in therapeutic options available to patients. Epidermal growth factor receptor (EGFR) hyperexpression is one of the most commonly encountered abnormalities in this tumor. However, EGFR
Roger E, McLendon, Kristi, Turner, Kathryn, Perkinson, Jeremy, Rich   +3 more
openaire   +2 more sources

Cosmological vacuum selection and metastable susy breaking [PDF]

, 2010
We study gauge mediation in a wide class of O'Raifeartaigh type models where supersymmetry breaking metastable vacuum is created by gravity and/or quantum corrections.
A Katz, C Cheung, C Papineau, CR Nappi, D Shih, E Dudas, EF Moreno, GF Giudice, GN Felder, H Murayama, H Murayama, Ioannis Dalianis, JJ Heckman, JL Feng, JR Ellis, KA Intriligator, KA Intriligator, L Anguelova, L Kofman, L O’Raifeartaigh, L Álvarez-Gaumé, M Dine, M Dine, M Dine, M Dine, M Dine, M Dine, M Dine, M Ibe, M Ibe, M Olechowski, NJ Craig, P Binetruy, P Langacker, R Kitano, S Dimopoulos, S Dimopoulos, S Dimopoulos, SA Abel, SA Abel, T Jelinski, V Mukhanov, W Fischler, Z Komargodski, Z Lalak, Zygmunt Lalak   +45 more
core   +2 more sources

Ca²⁺ Signaling by TRPV4 Channels in Respiratory Function and Disease

Cells, 2021
Members of the transient receptor potential (TRP) superfamily are broadly expressed in our body and contribute to multiple cellular functions. Most interestingly, the fourth member of the vanilloid family of TRP channels (TRPV4) serves different ...
Suhasini Rajan, Christian Schremmer, Jonas Weber, Philipp Alt, Fabienne Geiger, Alexander Dietrich   +5 more
doaj   +1 more source

Destruction of self-derived PAMP via T3SS2 effector VopY to subvert PAMP-triggered immunity mediates Vibrio parahaemolyticus pathogenicity

Cell Reports, 2023
Summary: Cyclic di-guanosine monophosphate (c-di-GMP) is a unique bacterial second messenger but is hijacked by host cells during bacterial infection as a pathogen-associated molecular pattern (PAMP) to trigger STING-dependent immune responses.
Xuan Wu, Lantian Zhou, Chen Ye, Zhenzhong Zha, Chuchu Li, Chao Feng, Yue Zhang, Qian Jin, Jianyi Pan   +8 more
doaj   +1 more source

Global Regulator MorA Affects Virulence-Associated Protease Secretion in Pseudomonas aeruginosa PAO1.

PLoS ONE, 2015
Bacterial invasion plays a critical role in the establishment of Pseudomonas aeruginosa infection and is aided by two major virulence factors--surface appendages and secreted proteases.
Ayshwarya Ravichandran, Malarmathy Ramachandran, Tanujaa Suriyanarayanan, Chui Ching Wong, Sanjay Swarup   +4 more
doaj   +1 more source

Cell cycle control and environmental response by second messengers in Caulobacter crescentus

BMC Bioinformatics, 2020
Background Second messengers, c-di-GMP and (p)ppGpp, are vital regulatory molecules in bacteria, influencing cellular processes such as biofilm formation, transcription, virulence, quorum sensing, and proliferation.
Chunrui Xu, Bronson R. Weston, John J. Tyson, Yang Cao   +3 more
doaj   +1 more source

The P34 Syringolide Elicitor Receptor Interacts with a Soybean Photorespiration Enzyme, NADH-Dependent Hydroxypyruvate Reductase

Molecular Plant-Microbe Interactions, 2002
The syringolide receptor P34 mediates avrD-Rpg4 gene-for-gene complementarity in soybean. However, the mechanism underlying P34 signal transmission after syringolide binding is unknown.
Yasushi Okinaka, Ching-Hong Yang, Eliot Herman, Anthony Kinney, Noel T. Keen   +4 more
doaj   +1 more source