Results 301 to 310 of about 539,249 (323)
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Differentiation of second messenger systems in mast cell activation
Agents and Actions, 1989Pretreatment of rat peritoneal mast cells with either Staurosporine or an analog K-252a, lead to a dose-related inhibition of histamine release when stimulated with Anti-IgE (IC50: Staurosporine = 110 nM; K-252a = 100 nM). In contrast, the two PKC inhibitors (1-1000 nM) failed to inhibit histamine release induced by compound 48/80 (0.5-1 micrograms/ml).
J R, White, D, Zembryki
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Second Messenger Systems Involved in Heart Mechanotransduction
2007Mechanical stress can be considered one of the major stimuli that evoke hypertrophic responses including reprogramming of gene expression in cardiac myocytes. Therefore, it is important to understand how mechanical loading is sensed by cardiomyocytes and converted into intracellular biomechanical signals leading to cardiac hypertrophy.
Hiroshi Hasegawa +4 more
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Dynamic Interactions of the Second Messenger Systems
1988The response of living cells to changes in cell environment depends on the production and actions of second messenger molecules. The two most extensively studied second messengers are Ca2+ and cAMP, each of which has been demonstrated to regulate unique metabolic reactions and pathways.
Chiayeng Wang +2 more
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Phospholipid Metabolism and Second Messenger System After Brain Ischemia
1992To evaluate possible involvement of phospholipid metabolism and related second messenger systems in the selective neuronal damage after ischemia, we measured changes of polyphosphoinositides (PPIs) and free fatty acids (FFAs) in a model of 5-min or 10-min ischemia and reperfusion in gerbils.
K, Abe +4 more
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Hepoxilins Modulate Second Messenger Systems in the Human Neutrophil
1991In this chapter, we will review recent findings which implicate the hepoxilins as modulators of second messenger systems in the human neutrophil. We have shown that the hepoxilins affect calcium homeostasis in the cell and that they stimulate the release of arachidonic acid and diradylglycerol but not inositol phosphate indicating a mode of action for ...
C R, Pace-Asciak, S, Nigam
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Zebrafish Melanophores: A Model for Teaching Second Messenger Systems
Zebrafish, 2016A strong literature base supports the notion that active learning improves retention in the science classroom. To that end, a course was designed to allow students to develop their own experiments around a central biological question. The model system used in this particular course is control of melanosome dispersal via second messenger systems in ...
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Calmodulin and Its Role in the Second-Messenger System
1979Publisher Summary This chapter provides an overview of calmodulin and its role in the second-messenger system. Calmodulin is a ubiquitous regulatory protein of the second-messenger system. It exhibits Ca2+-dependent regulatory activities toward several enzymes and proteins.
J H, Wang, D M, Waisman
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Excitatory Amino Acids and Second Messenger Systems
19911 Diversity and Organization of Excitatory Amino Acid Receptors in the CNS.- 2 Molecular Biology of Glutamate-Gated Channels: Focus on AMPA and Kainate.- 3 From Excitatory Amino Acid Receptors to Long-Term Potentiation: An Insight into the Role of Ca2+.- 4 Evidence that Arachidonic Acid Plays a Role in Long-Term Potentiation.- 5 Glutamate Release by ...
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Histamine Receptors and Interactions between Second Messenger Transduction Systems
1991Histamine H1- and H2-receptors have been classically associated with two distinct intracellular second messenger systems. H2-receptors are coupled via a Gs regulatory protein to adenylate cyclase and stimulate cyclic AMP formation, while H1-receptors mediate many of their effects via the products of inositol phospholipid hydrolysis.
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Second-Messenger Systems Coupled to Metabotropic Glutamate Receptors
1994Glutamate and other excitatory amino acids (EAAs) have long been known to increase the levels of various second-messenger systems in different nervous system preparations. However, until recent years, these effects were generally held to be secondary to activation of glutamate-gated cation channels, and subsequent increases in neurotransmitter release ...
P. Jeffrey Conn +2 more
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