Results 41 to 50 of about 539,249 (323)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Ubiquitous purine sensor modulates diverse signal transduction pathways in bacteria

Nature Communications
Purines and their derivatives control intracellular energy homeostasis and nucleotide synthesis, and act as signaling molecules. Here, we combine structural and sequence information to define a purine-binding motif that is present in sensor domains of ...
Elizabet Monteagudo-Cascales, Vadim M. Gumerov, Matilde Fernández, Miguel A. Matilla, José A. Gavira, Igor B. Zhulin, Tino Krell   +6 more
doaj   +1 more source

Sphingosine-1-phosphate: distribution, metabolism and role in the regulation of cellular functions [PDF]

The Ukrainian Biochemical Journal, 2013
The role of sphingosine-1-phosphate (S1P) in regulation of cellular functions and cell protection is reviewed. S1P, along with other sphingolipid metabolites, is believed to act as an intracellular second messenger and as an extracellular mediator ...
V. I. Morozov, G. A. Sakuta, M. I. Kalinski   +2 more
doaj   +1 more source

Gauge Mediation with D-term SUSY Breaking [PDF]

, 2007
We construct a gauge-mediation model with a D-term supersymmetry (SUSY) breaking. R-symmetry breaking necessary for generating the SUSY standard-model gaugino masses is given by gaugino condensation of a strongly coupled gauge theory in the hidden sector.
Antoniadis, Arkani-Hamed, Arkani-Hamed, Buican, Butti, Cohen, Dymarsky, Fox, Giudice, Giudice, Giudice, Ibe, Izawa, Klebanov, Klebanov, Luty, Martin, Masato Taki, Nelson, Ouyang, Poppitz, Seiberg, T.T. Yanagida, Taizan Watari, Y. Nakayama   +24 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

H2O2 inhibits ABA-signaling protein phosphatase HAB1. [PDF]

PLoS ONE, 2014
Due to its ability to be rapidly generated and propagated over long distances, H2O2 is an important second messenger for biotic and abiotic stress signaling in plants. In response to low water potential and high salt concentrations sensed in the roots of
Madhuri Sridharamurthy, Amanda Kovach, Yang Zhao, Jian-Kang Zhu, H Eric Xu, Kunchithapadam Swaminathan, Karsten Melcher   +6 more
doaj   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio

Frontiers in Microbiology, 2022
The cyclic GMP-AMP (cGAMP) synthase (cGAS) recognizes cytosolic DNA and synthesizes the second messenger, cGAMP, thus activating the adaptor protein stimulator of interferon genes (STING) and initiating the innate immune responses against microbial ...
Zengzeng Lu, Yuqian Fu, Xueyuan Zhou, Hekang Du, Qi Chen   +4 more
doaj   +1 more source

The adenylate cyclase receptor complex and aqueous humor formation. [PDF]

, 1984
The secretory tissue of the eye, the ciliary processes, contains an enzyme receptor complex, composed of membrane proteins, the catalytic moiety of the enzyme adenylate cyclase, a guanyl nucleotide regulatory protein (or N protein), and other features ...
Caprioli, J, Sears, M
core   +1 more source