Results 61 to 70 of about 539,249 (323)

Instant messaging clients - Relaxed, free & enjoyable English learning and training tools [PDF]

, 2007
In a demanding world of using English as a second language, computer technology and the internet are being dominantly used as they provide an incredible boost to language learning environment.
Abu Bakar, Hanif Suhairi, Mahadi, Rozilawati   +1 more
core  

CAPA neuropeptides and their receptor form an anti-diuretic hormone signalling system in the human disease vector, Aedes aegypti [PDF]

, 2020
Insect CAPA neuropeptides are homologs of mammalian neuromedin U and are known to influence ion and water balance by regulating the activity of the Malpighian ‘renal’ tubules (MTs).
Ber, Lindsay Taylor, Lajevardi, Aryan, Matei, Andreea, Paluzzi, Jean-Paul, Paputsis, Christine, Sajadi, Farwa, Uyuklu, Ali, Wahedi, Azizia   +7 more
core   +1 more source

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Second messenger systems underlying amine and peptide actions on cardiac muscle in the horseshoe crab, Limulus polyphemus [PDF]

, 1989
The biochemical mechanisms by which octopamine, catecholamines and the peptide proctolin exert their actions on Limulus cardiac muscle were investigated.
Groome, J. R., Watson, Winsor H., III
core   +2 more sources

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

In vivo Analysis of Cyclic di-GMP Cyclase and Phosphodiesterase Activity in Escherichia coli Using a Vc2 Riboswitch-based Assay

Bio-Protocol, 2018
Cyclic di-guanosine monophosphate (c-di-GMP) is a ubiquitous second messenger that regulates distinct aspects of bacterial physiology. It is synthesized by diguanylate cyclases (DGCs) and hydrolyzed by phosphodiesterases (PDEs).
Ying Liu, Hyunhee Kim, Ute Römling
doaj   +1 more source

Targeting N-type calcium channels in young-onset of some neurological diseases

Frontiers in Cell and Developmental Biology, 2022
Calcium (Ca 2+) is an important second messenger in charge of many critical processes in the central nervous system (CNS), including membrane excitability, neurotransmission, learning, memory, cell proliferation, and apoptosis.
Flavia Tasmin Techera Antunes, Flavia Tasmin Techera Antunes, Alessandra Hubner De Souza, Juliana Figueira, Nancy Scardua Binda, Vanice Paula Ricardo Carvalho, Luciene Bruno Vieira, Marcus Vinícius Gomez   +7 more
doaj   +1 more source

Kinetic-scale magnetic turbulence and finite Larmor radius effects at Mercury

, 2011
We use a nonstationary generalization of the higher-order structure function technique to investigate statistical properties of the magnetic field fluctuations recorded by MESSENGER spacecraft during its first flyby (01/14/2008) through the near Mercury ...
Alexandrova, Alexandrova, Alexandrova, Anderson, Anderson, Anderson, Angelopoulos, Antonova, B. J. Anderson, Baker, Baumjohann, Baumjohann, Biskamp, Blomberg, Boardsen, Boardsen, Borovsky, Borovsky, Borovsky, Büchner, Carreras, Chang, Chen, Delcourt, Delcourt, E. F. Donovan, Eastwood, Eastwood, Fairfield, Fujimoto, Fujimoto, G. V. Khazanov, Glassmeier, H. Korth, J. A. Slavin, Khazanov, Khazanov, Klimas, Kolmogorov, Korth, Lazarian, Li, Liu, Matthaeus, Matthaeus, Meyrand, Mininni, Monin, Mukai, Nagai, Nakamura, Ogilvie, Omidi, Panov, Politano, Pouquet, Pulkkinen, Raines, Roberts, Robinson, S. A. Boardsen, Sahraoui, Sahraoui, Schekochihin, Schekochihin, Sergeev, Servidio, Shiokawa, Singh, Slavin, Slavin, Slavin, Slavin, Slavin, Slavin, Slavin, Solomon, Stepanova, Stepanova, Sundberg, Terasawa, Trávníček, Tsyganenko, Uritsky, Uritsky, Uritsky, V. M. Uritsky, Vörös, Warhaft, Yordanova   +89 more
core   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor

Frontiers in Endocrinology, 2012
Taltirelin (TAL) is a thyrotropin-releasing hormone (TRH) analog that is approved for use in humans in Japan. In this study, we characterized TAL binding to and signaling by the human TRH receptor (TRH-R) in a model cell system.
Nanthakumar eThirunarayanan, Bruce M. Raaka, Marvin C Gershengorn   +2 more
doaj   +1 more source