Results 151 to 160 of about 1,865,436 (219)
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Opioid Receptor-Coupled Second Messenger Systems
Life Sciences, 1991Although pharmacological data provide strong evidence for different types of opioid receptors (e.g., mu, delta, and kappa), they share many common properties in their ability to couple to second messenger systems. All opioid receptor types are coupled to G-proteins, since agonist binding is diminished by guanine nucleotides and agonist-stimulated ...
Steven R. Childers
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Neural cell adhesion molecules influence second messenger systems
Neuron, 1989We have investigated the influence of the neural cell adhesion molecules L1 and N-CAM on second messenger systems using a PC12 rat pheochromocytoma cell line as a model and triggering cell surface receptors by specific antibody binding. Antibodies directed against L1 and N-CAM, but not against other cell surface components, reduce intracellular levels ...
U, Schuch, M J, Lohse, M, Schachner
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Beyond receptors: Multiple second‐messenger systems in brain
Annals of Neurology, 1987AbstractSecond‐messenger systems play a major role in mediating neurotransmitter actions. In recent years our understanding of the organization and function of two prominent second‐messenger systems has progressed rapidly—the adenylate cyclase and phosphoinositide systems. Guanosine triphosphate–binding proteins, which are especially abundant in brain,
P F, Worley, J M, Baraban, S H, Snyder
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Cyclic AMP second messenger systems
Current Opinion in Cell Biology, 1991Cells carefully regulate the generation and destruction of cAMP using diverse families of adenylate cyclases and phosphodiesterases. Genes for several cyclases have now been cloned, giving structural information about the enzymes and providing access to the remaining members of this family.
G. McKnight
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EXTENDED ROLES IN THE BRAIN FOR SECOND-MESSENGER SYSTEMS
Neuroscience, 1977Publisher Summary The term 'second messenger' is of biochemical origin and refers to an intracellular component of linked reaction-sequences by which cells or organs interact with each other. As a second messenger, cyclic AMP also performs several roles in the brain but the scope and coordination of these actions are still in the course of being ...
H. Mcilwain
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Olfactory transduction: cross-talk between second-messenger systems
Biochemistry, 1990Chemosensory cilia of olfactory receptor neurons contain an adenylate cyclase which is stimulated by high concentrations of odorants. Cyclic AMP produced by this enzyme has been proposed to act as second messenger in olfactory transduction. Here we report that olfactory cilia contain calmodulin and that calmodulin potently activates olfactory adenylate
R R, Anholt, A M, Rivers
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Second Messenger System in Neoplasia
Oncology, 1974Hormones have been observed to initiate tumors in animals and are thought to be involved in cellular selection and/or progression of neoplastic lesions in humans.
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