Results 161 to 170 of about 1,865,436 (219)

The Second-Messenger System for Peptide Hormones

Hospital Practice, 1989
There are three major hormone classes--peptide, steroid, and the newly defined growth factors--each with its own system for signal transduction in the cell. Two interdependent theses are proposed for the peptide hormone: that incoming signal transduction requires coupling to a G protein in a second-messenger pathway, and that second-messenger ...
R M, Hanley, A L, Steiner
openaire   +2 more sources

Immunocytochemistry of second messenger systems

Trends in Neurosciences, 1981
Abstract The physiological response of a cell to a neurotransmitter is dependent upon a chain of intracellular biochemical events, involving the cyclic nucleotides and Ca 2+ . These ‘second messenger' systems may occur in a variety of neuronal, glial, vascular or connective tissue cell types in the brain.
openaire   +1 more source

Second Messenger Systems in the Brain

1982
About 25 years ago, Sutherland and his colleagues made an important discovery. Epinephrine and glucagon, acting as hormones, were both known to be able to profoundly affect the activity of the liver phosphorylase that catalyzes the conversion of glycogen to glucose 1-phosphate. Sutherland and Rail (1958), however, noted that the hormonal stimulation of
Stanislav Reinis, Jerome M. Goldman
openaire   +1 more source

Astrocytic receptors and second messenger systems

2003
Publisher Summary This chapter reviews that glial cells support neuronal activity and create opportunities for the dynamics and plasticity of the central nervous system (CNS). After injury, metabolic disturbance or toxic influence, and in degenerative disease, glial cell reactions protect neurons and facilitate rebuilding. It explores that astrocytes
Elisabeth Hansson∗, Lars Rönnbäck
openaire   +1 more source

Regulation of Second Messenger Systems and Intracellular Pathways

2009
The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell ...
MERIGHI, Stefania, SIMIONI, Carolina, R. Lane, A. P. Ijzerman   +3 more
openaire   +2 more sources

Pharmacology of stomoxytachykinin receptor depends on second messenger system

Peptides, 2005
STKR is a neurokinin receptor derived from the stable fly, Stomoxys calcitrans. Insect tachykinin-related peptides, also referred to as "insectatachykinins", produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned STKR cDNA. Pronounced differences in
Poels, J., Nachman, R.J., Akerman, K.E., Oonk, H.B., Guerrero, F., de Loof, A., Janecka, A.E., Torfs, H., Vanden Broeck, J.   +8 more
openaire   +3 more sources

Opioid-Coupled Second Messenger Systems

1988
Receptors are normally considered as composed of two separate parts: a specific ligand binding site and an effector component that causes a specific biological response subsequent to agonist binding. Historically, neurotransmitter receptors have been identifed by both properties.
openaire   +1 more source

The second messenger system as the morphogenetic field

Biochemical and Biophysical Research Communications, 1989
For sixty years morphogenetic fields have been assumed. We suggest a realization for such a field: the second messenger (in particular cyclic AMP) and its substrate (in particular ATP) are suggested to be the activator-morphogen and inhibitor respectively. Gene transcription is derived as an hysteretic function of the second messenger (cyclic AMP).
openaire   +2 more sources

Second Messenger Systems and Signal Transduction Mechanisms

1997
Hormones are secreted, reach their target, and bind to a receptor. The interaction of the hormone with the receptor produces an initial signal that, through a series of steps, results in the final hormone action. How does the binding of a hormone to a receptor result in a cellular action?
openaire   +1 more source

Second Messenger Systems Underlying Plasticity at the Neuromuscular Junction

International Review of Neurobiology, 1999
Publisher Summary The Drosophila neuromuscular junction provides elegant significant experimental model to study signal transduction pathways that mediate synaptic plasticity because of its accessibility to electrophysiological techniques, morphological analyses, and pharmacological and genetic manipulations at identifiable synapses.
F, Hannan, Y, Zhong
openaire   +2 more sources