Results 81 to 90 of about 4,820 (302)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Properties of Electrode Induction Melting Gas Atomization- and Vacuum Induction Melting Atomization-Produced Powders and Their As-HIPed Blanks. [PDF]

Materials (Basel)
The main method for large-scaled preparing powder superalloys in the production process is inert gas atomization, particularly vacuum-induced gas atomization (VIGA).
Ren X, Wang Y, Wang Z, Wang P, Wang Z, Yang L, Qi W, Li X, Ge C.   +8 more
europepmc   +2 more sources

Surface sensitivity of atomic-resolution secondary electron imaging

Microscopy
Abstract The surface sensitivity of high-resolution secondary electron (SE) imaging is examined using twisted bilayers of MoS2 stacked at an angle of 30°. High-resolution SE images of the twisted bilayer MoS2 show a honeycomb structure composed of Mo and S atoms, elucidating the monolayer structure of MoS2.
Saitoh, Koh, Oyobe, Teppei, Igarashi, Keisuke, Sato, Takeshi, Matsumoto, Hiroaki, Inada, Hiromi, Endo, Takahiko, Miyata, Yasumitsu, Usami, Rei, Takenobu, Taishi   +9 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Numeral simulation of droplet evaporation-atomization under hot air flow

Case Studies in Thermal Engineering
In the field of cerium oxide preparation by spray pyrolysis, understanding the droplet atomization-evaporation process is an innovative and promising concept.
Chao Lv, Lu-Lu Zhang, Ning Wei, Xu-Xin Chen, Hong-Liang Zhao, Wei-Guang Hao   +5 more
doaj   +1 more source

Secondary Atomization of a Biodiesel Micro-Emulsion Fuel Droplet Colliding with a Heated Wall

Applied Sciences, 2020
Using high-speed video recording, we establish the following regimes of hydrodynamic interaction of a biodiesel micro-emulsion fuel droplet with a heated wall: deposition (including drop spreading and receding), drop hydrodynamic breakup, and rebound ...
Alexander E. Ashikhmin, Nikita A. Khomutov, Maxim V. Piskunov, Vyacheslav A. Yanovsky   +3 more
doaj   +1 more source

Secondary atomization of liquid columns in compressible crossflows

, 2019
The secondary atomization of liquid droplets is a common physical phenomenon in many industrial and engineering applications. Atomization in high speed compressible flows is less well understood than its more frequently studied low Mach number counterpart.
Garrick, Daniel P., Hagen, Wyatt A., Regele, Jonathan D.   +2 more
openaire   +2 more sources

Effect of Particle Concentration on Shape Deformation and Secondary Atomization Characteristics of a Burning Nanotitania Dispersion Droplet

, 2015
Secondary atomization characteristics of burning bicomponent (ethanol-water) droplets containing titania nanoparticles (NPs) in dilute (0.5% and 1 wt.%) and dense concentrations (5% and 7.5 wt.%) are studied experimentally at atmospheric pressure under ...
Basu, Saptarshi, Miglani, Ankur
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source