Results 61 to 70 of about 3,130,306 (355)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Journal of Hebei University of Science and Technology, 2018 In order to enhance the heat transfer performance of CO2 heat pump, based on the numerical simulation method of Fluent, the law of supercritical CO2 cooling and heat transfer characteristics and secondary flow in the horizontal elliptical tube whose ...
Haiting CUI, Changle YI, Siwen LIU
doaj +1 more source
Drag reduction within radial turbine rotor passages using riblets [PDF]
, 2018 In this paper, reducing the friction losses in a radial inflow turbine rotor surface by adding engineered features (riblets) is explored. Initially, computational fluid dynamics analysis was used to study the operating mechanism of riblets and to test ...
Khader, M. A., Sayma, A. I.
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Aerodynamic Shape Optimization of Wing–Fuselage Intersection for Minimum Interference Drag
AerospaceInterference drag in wing–fuselage intersection regions is a complex aerodynamic phenomenon where secondary flows and separation conditions might occur if not properly addressed in the aircraft design.
Nuno M. B. Matos, André C. Marta
doaj +1 more source
Secondary vortices in swirling flow [PDF]
, 2010 Twisted tapes are used to induce swirling flow and improve mixing. The flow induced by a 180 degree twisted tape with length (pitch) 60 mm and diameter 25.4 mm in a circular pipe was investigated using Laser Doppler Velocimetry (LDV) measurements ...
Aidun, Cyrus K., Cazan, Radu
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Contact Discontinuities in Models of Contact Binaries Undergoing Thermal Relaxation Oscillations [PDF]
, 1999 In this paper we pursue the suggestion by Shu, Lubow & Anderson (1979) and Wang (1995) that contact discontinuity (DSC) may exist in the secondary in the expansion TRO (thermal relaxation oscillation) state.
Biermann P. +16 more
core +2 more sources
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source