Results 61 to 70 of about 3,135,634 (302)

Numerical simulation of cooling heat transfer of supercritical carbon dioxide in twisted elliptical tubes

Journal of Hebei University of Science and Technology, 2018
In order to enhance the heat transfer performance of CO2 heat pump, based on the numerical simulation method of Fluent, the law of supercritical CO2 cooling and heat transfer characteristics and secondary flow in the horizontal elliptical tube whose ...
Haiting CUI, Changle YI, Siwen LIU
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Aerodynamic Shape Optimization of Wing–Fuselage Intersection for Minimum Interference Drag

Aerospace
Interference drag in wing–fuselage intersection regions is a complex aerodynamic phenomenon where secondary flows and separation conditions might occur if not properly addressed in the aircraft design.
Nuno M. B. Matos, André C. Marta
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

An Overview of Viscous and Highly Viscous Fluid Flows in Straight and Elbow Pipes: I—Single-Phase Flows

Fluids
The flow of viscous and highly viscous fluids in straight and bent pipes and channels is a fundamental process in a wide variety of industrial applications and is, therefore, of great interest in science and engineering.
Leonardo Di G. Sigalotti, Enrique Guzmán   +1 more
doaj   +1 more source

Turbulence-induced secondary motion in a buoyancy-driven flow in a circular pipe. [PDF]

, 2009
We analyze the results of a direct numerical simulation of the turbulent buoyancy-driven flow that sets in after two miscible fluids of slightly different densities have been initially superimposed in an unstable configuration in an inclined circular ...
Hallez, Yannick, Magnaudet, Jacques
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Numerical Investigation of Secondary Flow and Loss Development in a Low-Pressure Turbine Cascade with Divergent Endwalls

International Journal of Turbomachinery, Propulsion and Power, 2018
Secondary flow and loss development in the T106Div-EIZ low-pressure turbine cascade are investigated utilizing (U)RANS simulations in cases with and without periodically incoming wakes at M a 2 t h = 0 . 59 and R e 2 t h = 2 × 10 5
Roberto Ciorciari, Tobias Schubert, Reinhard Niehuis   +2 more
doaj   +1 more source