Results 61 to 70 of about 358,984 (291)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Self-Adaptive Secondary Frequency Regulation Strategy Based on Distributed Model Predictive Control
Shanghai Jiaotong Daxue xuebaoTo address the issues of reduced adaptability of secondary frequency regulation caused by changes in power system parameters, a self-adaptive secondary frequency regulation strategy based on distributed model predictive control (DMPC) is proposed. First,
CAO Yongji, ZHANG Jiangfeng, WANG Tianyu, ZHENG Keke, WU Qiuwei
doaj +1 more source
Wind farms providing secondary frequency regulation: evaluating the performance of model-based receding horizon control [PDF]
Wind Energy Science, 2018 This paper is an extended version of our paper presented at the 2016 TORQUE conference (Shapiro et al., 2016). We investigate the use of wind farms to provide secondary frequency regulation for a power grid using a model-based receding horizon control ...
C. R. Shapiro +3 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Optimization Scheduling of Multi-Regional Systems Considering Secondary Frequency Drop [PDF]
After primary frequency regulation in large-scale wind farms is completed, the power dip phenomenon occurs during the rotor speed recovery phase. This phenomenon may induce a secondary frequency drop in power systems, which poses challenges to system ...
Tao Wang +4 more
core +1 more source
Performance Analysis of Distributed Control Strategies for Frequency Regulation Support by Domestic Thermal Loads [PDF]
, 2018 This paper deals with the control of aggregated domestic thermostatic loads, as refrigerators and water heaters, in order to provide an effective support to the primary frequency regulation, without compromising the secondary frequency regulation and the
Crosa Di Vergagni, Monica +11 more
core +1 more source
Inter-Provincial Tie-Line Power Assessment Mechanism and Model for Spot Market
Shanghai Jiaotong Daxue xuebaoMultiple regional power grids in China have adopted the control performance standard (CPS) to assess the performance of inter-provincial tie-line operations, which has played a significant role in the reduction of both power deviation on inter-provincial
CHEN Zijie, SONG Bingbing, LI Yutong, WANG Lifeng, TENG Xiaobi, YAN Zheng, CHEN Sijie
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source