Results 191 to 200 of about 3,074,415 (252)

N6-methyladenosine (m6A)-circHECA from secondary hair follicle of cashmere goats: identification, regulatory network and expression regulated potentially by methylation of its host gene promoter. [PDF]

Anim Biosci
Shen J, Hui T, Bai M, Fan Y, Zhu Y, Zhang Q, Xu R, Zhang J, Wang Z, Zheng W, Bai W.   +10 more
europepmc   +1 more source

Generalised alopecia caused by iatrogenic supplementation of estriol for treatment of urinary incontinence in a 13‐year‐old, spayed, female miniature poodle

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract Urinary incontinence is a disorder associated with involuntary leakage of urine. Multiple estrogenic compounds have been used to manage urinary incontinence. While treatment for urinary incontinence will undoubtedly improve the quality of life for both the owner and the pet, it is not without potential side effects.
Brenda L. Mulherin, Olivia Stricklin, Jame O. Noxon   +2 more
wiley   +1 more source

Putative lotilaner/milbemycin‐induced Stevens‐Johnson syndrome/toxic epidermal necrolysis in a dog

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract Stevens‒Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, severe skin and mucocutaneous reaction, characterised by extensive epidermal necrosis and skin sloughing. Drugs are common triggers, with reactions to a number of classes reported.
Matt McHale, Liam Wilson, Tim Nuttall, Victoria Robinson   +3 more
wiley   +1 more source

Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Shaianne N. Stein, Lorena R. Braid
wiley   +1 more source

Review Article: Fibrosis Reversal in Metabolic Dysfunction‐Associated Steatohepatitis—The Promise of Emerging Therapeutics

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 9, Page 1184-1196, November 2026.
Metabolic dysfunction‐associated steatohepatitis is the second commonest US indication for liver transplantation but remains largely undiagnosed and untreated. Fibrosis stage is the strongest predictor of major adverse liver outcomes, with decompensation rates and transplant‐free survival diverging sharply between F3 and F4, while cardiovascular ...
Malek Ayoub, Tsubasa Tsutsumi, Mary E. Rinella   +2 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Transverse Histological Analysis of Scalp Seborrheic Dermatitis: A Novel Perspective

Journal of Cutaneous Pathology, Volume 53, Issue 11, Page 1055-1061, November 2026.
ABSTRACT Background Seborrheic dermatitis is a chronic inflammatory disease affecting seborrheic areas of the skin, including the scalp. It is often confused with scalp psoriasis due to similar clinical and histopathological features. Objective This study described microscopic changes in the pilosebaceous unit in seborrheic dermatitis (SDS) using cross‐
Tatiane Elen de Souza, Almut Böer‐Auer, Betina Werner   +2 more
wiley   +1 more source

Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors

Journal of Cutaneous Pathology, Volume 53, Issue 11, Page 1042-1050, November 2026.
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He, Shaymaa Hegazy, Phyu P. Aung, Priyadharsini Nagarajan, Fiorinda Muhaj, Adrienne N. Choksi, Ana M. Ciurea, Kelly C. Nelson, Doina Ivan, Carlos A. Torres‐Cabala, Victor G. Prieto, Jonathan L. Curry   +11 more
wiley   +1 more source

The Cutaneous Melatoninergic System: Endogenous Biology and Potential for Therapeutic Targeting

Experimental Dermatology, Volume 35, Issue 11, November 2026.
ABSTRACT Melatonin is best known as a pineal hormone that regulates circadian rhythms, but the skin also possesses an intrinsic melatoninergic system capable of local synthesis, metabolism and signalling. This system encompasses classical melatonin receptors, biologically active metabolites, non‐classical signalling pathways and receptor‐independent ...
Ju Hee Han, Hei Sung Kim
wiley   +1 more source

Characterisation of human hair follicle development

Journal of Anatomy, Volume 249, Issue 5, Page 1033-1049, November 2026.
Schematic of hair follicle development in human skin. Hair follicle primordia of similar sizes, but different densities, are laid out across the skin. The distinction between terminal and vellus hair sites is not obvious at early stages of hair follicle development.
Zoe R. Sudderick, James D. Glover, Cameron Batho‐Samblas, Barbara Bo‐Ju Shih, Denis J. Headon   +4 more
wiley   +1 more source