Results 61 to 70 of about 3,005,072 (284)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Secondary immunodeficiencies, including HIV infection [PDF]

Journal of Allergy and Clinical Immunology, 2010
Extrinsic factors can adversely affect immune responses, producing states of secondary immunodeficiency and consequent increased risk of infections. These immunodeficiencies, which can be encountered in routine clinical practice, arise from a number of conditions, such as treatment with glucocorticoids and immunomodulatory drugs, surgery and trauma ...
Javier, Chinen, William T, Shearer
openaire   +2 more sources

Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection [PDF]

, 1991
Fuchs D, Krämer A, Reibnegger G, et al. Neopterin and [beta]2-microglobulin as prognostic indices in human immunodeficiency virus type 1 infection. Infection.
Werner, Ernst R., Fuchs, Dietmar, Krämer, Alexander ; https://orcid.org/, Goedert, James J., Reibnegger, Gilbert, Dierich, M. P., Wachter, Helmut   +6 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Features of purulent mediastinitis in patients with comorbid secondary immunodeficiency

Український журнал клінічної хірургії
Objective. To characterize the immune response in patients with purulent mediastinitis against the background of secondary immunodeficiency and to justify targeted surgical treatment of purulent-septic complications. Materials and methods. The results
V. O. Shaprinskyi, V. F. Kryvetskyi, E. V. Shaprinskyi, B. O. Mitiuk, O. O. Vorovskyi, V. H. Suleimanova, M. A. Verba   +6 more
doaj   +1 more source

MULTIVARIATE MODELLING OF THE IMMUNE STATUS IN DETECTION OF SECONDARY IMMUNODEFICIENCY AND THE ALLERGY

Медицинская иммунология, 2017
Immune status of healthy people, patients with secondary immunodeficiency and allergic diseases is assessed. To reduce the number of characteristics of immunity (23 indicators) to a number of the generalizing factors the multivariate analysis is used ...
E. G. Kuzmina, S. V. Zatsarenko
doaj   +1 more source

Clinical characteristics and lung function in older children vertically infected with Human Immunodeficiency Virus in Malawi [PDF]

, 2015
T. M. was funded by the Commonwealth scholarship, with research costs from a grant fom Helse Nord Northern Norway Regional Health Authority. E. L. C., R. A. F., and J. R. are supported by Wellcome Trust Fellowships (Senior Fellowship in Clinical Sciences
Webb, Emily L, Rylance, Sarah J, van Oosterhout, Joep J, Emily L. Webb, Mwalukomo, Thandie, Anderson, Suzanne, O'Hare, Bernadette, Elizabeth L. Corbett, Corbett, Elizabeth L, Webb, Emily, Jamie Rylance, Ferrand, Rashida A., van Oosterhout, Joep J., Corbett, Elizabeth L., Sarah J. Rylance, Ferrand, Rashida A, Rashida A. Ferr, Rylance, Jamie, Joep J. Van Oosterhout, Rylance, Sarah, O'Hare, Bernadette Ann-Marie, Suzanne Anderson, Ie Mwalukomo   +22 more
core   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Ozone as an Immunomodulator—New Therapeutic Possibilities in the Treatment of Immunodeficiencies—A Narrative Review

Current Issues in Molecular Biology
Research Subject: Primary and secondary immunodeficiencies represent a growing clinical and public health challenge due to increased susceptibility to infections, impaired immune regulation, chronic inflammation, and disturbances in redox homeostasis ...
Katarzyna Napiórkowska-Baran, Jozef Slawatycki, Paula Klemenska, Paweł Treichel, Ardem Najarian, Gary Andrew Margossian, Maciej Szota, Maria Plocka-Karpinska, Michał Kułakowski   +8 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source