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Innate lymphoid cells in secondary lymphoid organs
Immunological Reviews, 2016 SummaryThe family of innate lymphoid cells (ILCs) has attracted attention in recent years as its members are important regulators of immunity, while they can also cause pathology. In both mouse and man, ILCs were initially discovered in developing lymph nodes as lymphoid tissue inducer (LTi) cells.
Reina E Mebius
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Cooperating Mechanisms of CXCR5 and CCR7 in Development and Organization of Secondary Lymphoid Organs [PDF]
Journal of Experimental Medicine, 2003 Homeostatic chemokines participate in the development of secondary lymphoid organs and later on in the functional organization of these tissues. The development of lymph nodes (LNs) and Peyer's patches depends on the recruitment of CD3− CD4+ interleukin (IL)-7Rαhi cells to sites of future organ development.
Reinhold Forster +2 more
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Chemokines and Cell Migration in Secondary Lymphoid Organs
Science, 1999As few as one in 100,000 B and T lymphocytes are specific for a single protein antigen, such as tetanus toxin, yet these cells must come together if an antibody response is to occur. Bringing antigen-presenting cells and rare antigen-specific B and T lymphocytes into physical contact is a principal function of secondary lymphoid organs. In the last few
Jason Cyster
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Secondary Lymphoid Organs Are Important But Not Absolutely Required for Allograft Responses [PDF]
American Journal of Transplantation, 2003 The role of secondary lymphoid organs in adaptive immune responses following transplantation is controversial. To examine the requirement for peripheral lymphoid organs in mounting immune responses to transplantation antigens, lymphotoxin alpha-deficient (LTalpha-/-) and LTbeta-receptor-deficient (LTbetaR-/-) mice that lack lymph nodes and Peyer's ...
Maria-Luisa Alegre +2 more
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Chemokines as organizers of primary and secondary lymphoid organs
Seminars in Immunology, 2003Lymphoid organs represent highly specialized tissues enabling the development and activation of B and T lymphocytes. Contact between lymphoid and parenchymal cells in bone marrow and thymus is a prerequisite for proper development of B and T cells, respectively, while secondary lymphoid organs, such as spleen and lymph nodes are the places where B and ...
Lars, Ohl +3 more
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Modeling immune reactivity in secondary lymphoid organs
Bulletin of Mathematical Biology, 1992Models of the dynamical interactions important in generating immune reactivity have generally assumed that the immune system is a single well-stirred compartment. Here we explicitly take into account the compartmentalized nature of the immune system and show that qualitative conclusions, such as the stability of the immune steady state, depend on ...
Perelson, Alan S., Weisbuch, Gérard
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Lymphocyte tracking and interactions in secondary lymphoid organs
Inflammation Research, 2007The induction of an adaptive immune response is an essential step in the generation of long-lasting, protective immunity to pathogens. Many studies over the last few decades have identified the cell populations involved in the generation of antigen-specific immunity and elucidated the role of many important molecules.
Brewer, J.M. +4 more
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Cytokine regulation of secondary lymphoid organ development
Current Opinion in Immunology, 1998Lymphotoxin and tumor necrosis factor provide essential signals for the formation of secondary lymphoid tissue structures. Lymphotoxin in its membrane form (LT alpha 1 beta 2 heterotrimer) is required for the development of lymph nodes and Peyer's patches and supports the development of normal spleen structure.
D D, Chaplin, Y, Fu
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Elucidating the functional anatomy of secondary lymphoid organs
Current Opinion in Immunology, 2004Functional anatomy offers an attempt to exploit anatomical information as a platform from which to decipher mechanistic details of complex or multistep immunological processes. Immune function depends on structural organization, therefore this approach contributes to a comprehensive understanding of the immune system.
Oliver, Pabst +3 more
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Age-Related Changes in Primary and Secondary Lymphoid Organs
Healthy Ageing and Longevity, 2021Valquiria Bueno
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