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Functional Organization of Secondary Lymphoid Organs by the Chemokine System
2000The development of an adaptive immune response requires well coordinated mechanisms in order to navigate circulating immune cells through peripheral tissues and into secondary lymphoid organs. There is strong experimental evidence that chemokines and their receptors are responsible for recruiting cells involved in inflammatory processes as well as for ...
M, Lipp +6 more
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Chemokines and Cell Migration in Secondary Lymphoid Organs
Science, 1999As few as one in 100,000 B and T lymphocytes are specific for a single protein antigen, such as tetanus toxin, yet these cells must come together if an antibody response is to occur. Bringing antigen-presenting cells and rare antigen-specific B and T lymphocytes into physical contact is a principal function of secondary lymphoid organs. In the last few
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Clinical Immunology, Endocrine & Metabolic Drugs, 2018
Background: Secondary lymphoid organs (SLO) are distributed in many districts of the body and, especially, lymph nodes, spleen and gut-associated lymphoid tissue are the main cellular sites. On the other hand, tertiary lymphoid organs (TLO) are formed in response to inflammatory, infectious, autoimmune and neoplastic events. Developmental Studies:
Magrone T., Jirillo E.
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Background: Secondary lymphoid organs (SLO) are distributed in many districts of the body and, especially, lymph nodes, spleen and gut-associated lymphoid tissue are the main cellular sites. On the other hand, tertiary lymphoid organs (TLO) are formed in response to inflammatory, infectious, autoimmune and neoplastic events. Developmental Studies:
Magrone T., Jirillo E.
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Development of Secondary Lymphoid Organs in Relation to Lymphatic Vasculature
2013Although the initial event in lymphatic endothelial specification occurs slightly before the initiation of lymph node formation in mice, the development of lymphatic vessels and lymph nodes occurs within the same embryonic time frame. Specification of lymphatic endothelial cells starts around embryonic day 10 (E10), followed by endothelial cell budding
van de Pavert, S.A., Mebius, R.E.
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Antigen trapping in Ambystoma mexicanum role of secondary lymphoid organs
Developmental & Comparative Immunology, 1981Abstract The fate of radiolabelled polyvinylpyrrolidone (PVP), injected into neotenous adult Ambystoma mexicanum , showed antigen trapping exclusively by the spleen; low temperatures did not inhibit such trapping. Injection of horse erythrocytes (HRBCs) resulted in the apperance of specific rosette-forming cells (RFCs) in the spleen, liver and ...
A M, Tahan, R D, Jurd
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Expression and function of interleukin-7 in secondary and tertiary lymphoid organs
Seminars in Immunology, 2012Interleukin-7 (IL-7) is known since many years as stromal-cell derived cytokine that plays a key role for the adaptive immune system. It promotes lymphocyte development in the bone marrow and thymus as well as naive and memory T cell homeostasis in the periphery.
Huang Hsin-Ying, Luther Sanjiv A
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CNS: Not an immunoprivilaged site anymore but a virtual secondary lymphoid organ
International Reviews of Immunology, 2017The cardinal dogma of central nervous system (CNS) immunology believed brain is an immune privileged site, but scientific evidences gathered so far have overturned this notion proving that CNS is no longer an immune privileged site, but rather an actively regulated site of immune surveillance.
Neema, Negi, Bimal K, Das
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Tissue Engineering the Thymus and Secondary Lymphoid Organs
Postdoc Journal, 2013Tissue engineering is making great strides to repair disease and damage in a wide range of tissues, many of which are high profile and well documented. However, the thymus and secondary lymphoid organs are tissues which have not received significant attention from the research community but are nonetheless important targets for tissue engineering based
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Immunology letters, 2007
Lymphoid organs are generally classified in a hierarchy with primary lymphoid organs such as the thymus and bone marrow for the production of receptor specific T and B lymphocytes, respectively, independent of antigens. In secondary lymphoid organs such as lymph nodes, spleen, and tonsils, the lymphocytes are expanded due to antigen exposure, producing
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Lymphoid organs are generally classified in a hierarchy with primary lymphoid organs such as the thymus and bone marrow for the production of receptor specific T and B lymphocytes, respectively, independent of antigens. In secondary lymphoid organs such as lymph nodes, spleen, and tonsils, the lymphocytes are expanded due to antigen exposure, producing
openaire +1 more source