Results 41 to 50 of about 54,801 (253)

Regulation of adaptive immune responses by guiding cell movements in the spleen

Frontiers in Microbiology, 2015
The spleen combines the innate and adaptive immune systems in a uniquely organized way. The excision of spleen will induce many complications, especially the increased susceptibility to infections.
lintao ezhao, lina eliu, bo eguo, Bo eZhu   +3 more
doaj   +1 more source

Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response. [PDF]

PLoS ONE, 2014
Clusterin is a multifunctional protein that participates in tissue remodeling, apoptosis, lipid transport, complement-mediated cell lysis and serves as an extracellular chaperone. The role of clusterin in cancer and neurodegeneration has been extensively
Marina A Afanasyeva, Liudmila V Britanova, Kirill V Korneev, Nikita A Mitkin, Anna A Kuchmiy, Dmitry V Kuprash   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

BAFF induces CXCR5 expression during B cell differentiation in bone marrow

Biochemistry and Biophysics Reports, 2023
B cell activating factor (BAFF) plays an important role in antibody production through differentiation and maturation of B cells mainly in secondary lymphoid organs.
Hajime Koizumi, Wataru Fujii, Chizu Sanjoba, Yasuyuki Goto   +3 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Persistence and Responsiveness of Immunologic Memory in the Absence of Secondary Lymphoid Organs [PDF]

Immunity, 2006
Secondary lymphoid organs (SLOs) promote primary immune responses by recruiting naive lymphocytes and activated APCs. However, their role in the persistence or responsiveness of memory lymphocytes is unclear. We tested whether memory cells were maintained and could respond to challenge in the absence of SLOs.
Moyron-Quiroz, Juan E., Rangel-Moreno, Javier, Hartson, Louise, Kusser, Kim, Tighe, Michael P., Klonowski, Kimberly D., Lefrançois, Leo, Cauley, Linda S., Harmsen, Allen G., Lund, Frances E., Randall, Troy D.   +10 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity [PDF]

Immunological Reviews, 2012
SummarySecondary lymphoid organs (SLOs), including lymph nodes, Peyer's patches, and the spleen, have evolved to bring cells of the immune system together. In these collaborative environments, lymphocytes scan the surfaces of antigen‐presenting cells for cognate antigens, while moving along stromal networks.
Deepali, Malhotra, Anne L, Fletcher, Shannon J, Turley   +2 more
openaire   +2 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Inducing Ectopic T Cell Clusters Using Stromal Vascular Fraction Spheroid‐Based Immunotherapy to Enhance Anti‐Tumor Immunity

Advanced Science, 2022
Tertiary lymphoid structures (TLSs) provide specialized niches for immune cells, resulting in improved prognoses for patients undergoing cancer immunotherapy.
Jae‐Won Lee, Bum Chul Park, Na Yoon Jang, Sihyeon Lee, Young Kyu Cho, Prashant Sharma, Sang Won Byun, Kyeongseok Jeon, Yun‐Hui Jeon, Uni Park, Hyo Jin Ro, Hyo Ree Park, Yuri Kim, Dong‐Sup Lee, Seok Chung, Young Keun Kim, Nam‐Hyuk Cho   +16 more
doaj   +1 more source