Results 41 to 50 of about 54,493 (255)

Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response. [PDF]

PLoS ONE, 2014
Clusterin is a multifunctional protein that participates in tissue remodeling, apoptosis, lipid transport, complement-mediated cell lysis and serves as an extracellular chaperone. The role of clusterin in cancer and neurodegeneration has been extensively
Marina A Afanasyeva, Liudmila V Britanova, Kirill V Korneev, Nikita A Mitkin, Anna A Kuchmiy, Dmitry V Kuprash   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

BAFF induces CXCR5 expression during B cell differentiation in bone marrow

Biochemistry and Biophysics Reports, 2023
B cell activating factor (BAFF) plays an important role in antibody production through differentiation and maturation of B cells mainly in secondary lymphoid organs.
Hajime Koizumi, Wataru Fujii, Chizu Sanjoba, Yasuyuki Goto   +3 more
doaj   +1 more source

Persistence and Responsiveness of Immunologic Memory in the Absence of Secondary Lymphoid Organs [PDF]

Immunity, 2006
Secondary lymphoid organs (SLOs) promote primary immune responses by recruiting naive lymphocytes and activated APCs. However, their role in the persistence or responsiveness of memory lymphocytes is unclear. We tested whether memory cells were maintained and could respond to challenge in the absence of SLOs.
Moyron-Quiroz, Juan E., Rangel-Moreno, Javier, Hartson, Louise, Kusser, Kim, Tighe, Michael P., Klonowski, Kimberly D., Lefrançois, Leo, Cauley, Linda S., Harmsen, Allen G., Lund, Frances E., Randall, Troy D.   +10 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Secondary Lymphoid Organs Are Important But Not Absolutely Required for Allograft Responses [PDF]

American Journal of Transplantation, 2003
The role of secondary lymphoid organs in adaptive immune responses following transplantation is controversial. To examine the requirement for peripheral lymphoid organs in mounting immune responses to transplantation antigens, lymphotoxin alpha-deficient (LTalpha-/-) and LTbeta-receptor-deficient (LTbetaR-/-) mice that lack lymph nodes and Peyer's ...
Helen Robertson, Ping Zhou, Kwang Woo Hwang, David Palucki, Oliver Kim, Kenneth A. Newell, Yang-Xin Fu, Maria-Luisa Alegre   +7 more
openaire   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Inducing Ectopic T Cell Clusters Using Stromal Vascular Fraction Spheroid‐Based Immunotherapy to Enhance Anti‐Tumor Immunity

Advanced Science, 2022
Tertiary lymphoid structures (TLSs) provide specialized niches for immune cells, resulting in improved prognoses for patients undergoing cancer immunotherapy.
Jae‐Won Lee, Bum Chul Park, Na Yoon Jang, Sihyeon Lee, Young Kyu Cho, Prashant Sharma, Sang Won Byun, Kyeongseok Jeon, Yun‐Hui Jeon, Uni Park, Hyo Jin Ro, Hyo Ree Park, Yuri Kim, Dong‐Sup Lee, Seok Chung, Young Keun Kim, Nam‐Hyuk Cho   +16 more
doaj   +1 more source

Rejection of Tracheal Allograft by Intrapulmonary Lymphoid Neogenesis in the Absence of Secondary Lymphoid Organs

Transplantation, 2012
Obliterative bronchiolitis after lung transplantation is associated with intrapulmonary lymphoid neogenesis. The purpose of this study was to examine the role of lymphoid neogenesis, especially its relationship with secondary lymphoid organs (SLOs) in allograft airway rejection.A murine intrapulmonary tracheal transplant model and a conventional ...
Wagnetz, D, Sato, M, Hirayama, S, Matsuda, Y, Juvet, S, Yeung, J, Guan, Z, Zhang, L, Liu, M, Waddell, T, Keshavjee, S   +10 more
openaire   +2 more sources