Results 21 to 30 of about 54,801 (253)
Stroma cell priming in enteric lymphoid organ morphogenesis
Frontiers in Immunology, 2012 The lymphoid system is equipped with a network of specialized platforms located at strategic sites, which grant strict immune-surveillance and efficient immune responses.
Manuela eFerreira +2 more
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Chinese Journal of Lung Cancer, 2023 Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU +6 more
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Innate lymphoid cells in secondary lymphoid organs
Immunological Reviews, 2016 SummaryThe family of innate lymphoid cells (ILCs) has attracted attention in recent years as its members are important regulators of immunity, while they can also cause pathology. In both mouse and man, ILCs were initially discovered in developing lymph nodes as lymphoid tissue inducer (LTi) cells.
Bar-Ephraïm, JE, Mebius, Reina E.
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Context-Dependent Development of Lymphoid Stroma from Adult CD34+ Adventitial Progenitors
Cell Reports, 2016 Despite the key role of primary and secondary lymphoid organ stroma in immunity, our understanding of the heterogeneity and ontogeny of these cells remains limited.
Katarzyna M. Sitnik +7 more
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Frontiers in Immunology, 2012 In this communication, the contribution of stromal, or non-hematopoietic, cells to the structure and function of lymph nodes (LNs), as canonical secondary lymphoid organs (SLOs), is compared to that of tertiary lymphoid tissue or organs (TLOs), also ...
Sharon eStranford, Nancy H. Ruddle
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Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy
Frontiers in Immunology, 2023 ILC3s have been identified as crucial immune regulators that play a role in maintaining host homeostasis and modulating the antitumor response. Emerging evidence supports the idea that LTi cells play an important role in initiating lymphoid tissue ...
Yunshu Zhang +9 more
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Cooperating Mechanisms of CXCR5 and CCR7 in Development and Organization of Secondary Lymphoid Organs [PDF]
The Journal of Experimental Medicine, 2003 Homeostatic chemokines participate in the development of secondary lymphoid organs and later on in the functional organization of these tissues. The development of lymph nodes (LNs) and Peyer's patches depends on the recruitment of CD3− CD4+ interleukin (IL)-7Rαhi cells to sites of future organ development.
Ohl, L. +7 more
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Multi-tissue scRNA-seq reveals immune cell landscape of turbot (Scophthalmus maximus)
Fundamental Research, 2022 In vertebrates, bony fishes possess not only innate immune cells but also T and B cells that are equivalent to those in mammals. However, the precise sub-cluster of immune cells in teleost fish remains largely unknown.
Weijie Chen +8 more
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Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis
Frontiers in Cellular and Infection Microbiology, 2018 The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens.
Micely d'El-Rei Hermida +4 more
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The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures
Frontiers in Immunology, 2021 There is emerging evidence that the adaptive anti-tumor activity may be orchestrated by secondary lymphoid organ-like aggregates residing in the tumor microenvironment.
Roger Li +10 more
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