Results 21 to 30 of about 57,576 (254)

Multi-tissue scRNA-seq reveals immune cell landscape of turbot (Scophthalmus maximus)

Fundamental Research, 2022
In vertebrates, bony fishes possess not only innate immune cells but also T and B cells that are equivalent to those in mammals. However, the precise sub-cluster of immune cells in teleost fish remains largely unknown.
Weijie Chen, Jianchang Huang, Wei Wang, Ying Wang, Hao Chen, Qiyao Wang, Yuanxing Zhang, Qin Liu, Dahai Yang   +8 more
doaj   +1 more source

Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis

Frontiers in Cellular and Infection Microbiology, 2018
The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens.
Micely d'El-Rei Hermida, Caroline Vilas Boas de Melo, Isadora dos Santos Lima, Geraldo Gileno de Sá Oliveira, Washington L. C. dos-Santos   +4 more
doaj   +1 more source

The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures

Frontiers in Immunology, 2021
There is emerging evidence that the adaptive anti-tumor activity may be orchestrated by secondary lymphoid organ-like aggregates residing in the tumor microenvironment.
Roger Li, Roger Li, Anders Berglund, Logan Zemp, Jasreman Dhillon, Ryan Putney, Youngchul Kim, Rohit K. Jain, G. Daniel Grass, José Conejo-Garcia, James J. Mulé   +10 more
doaj   +1 more source

P03.03 Organization, function and gene expression of tertiary lymphoid structures in PDAC resembles lymphoid follicles in secondary lymphoid organs [PDF]

E-Poster Presentations, 2020
Background Secondary lymphoid organs (SLO) are involved in induction and enhancement of anti-tumor immune responses on different tumor entities. Recent evidence suggests that anti-tumor immune responses may also be induced or enhanced in the tumor microenvironment in so called tertiary lymphoid structures (TLS).
M Thelen, MA García-Márquez, T Nestler, S Wagener-Ryczek, J Lehmann, E Staib, F Popp, F Gebauer, P Lohneis, M Odenthal, S Merkelbach-Bruse, C Bruns, K Wennhold, M von Bergwelt-Baildon, HA Schlößer   +14 more
openaire   +1 more source

Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation.

Frontiers in Immunology, 2016
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid and stromal cells that provide ectopic hubs for acquired immune responses.
Francesca Barone, David Harry Gardner, Saba Nayar, Nathalie Steinthal, Christopher Buckley, Sanjiv A Luther   +5 more
doaj   +1 more source

The Spleen as a Target to Characterize Immunomodulatory Effects of Down-Stream Processed Cyberlindnera jadinii Yeasts in Atlantic Salmon Exposed to a Dietary Soybean Meal Challenge

Frontiers in Immunology, 2021
Aquaculture feeds have changed dramatically from being largely based on fishmeal (FM) towards increased use of plant protein sources, which could impact the fish’s immune response.
Byron Morales-Lange, Jeleel Opeyemi Agboola, Jon Øvrum Hansen, Leidy Lagos, Ove Øyås, Ove Øyås, Luis Mercado, Liv Torunn Mydland, Margareth Øverland   +8 more
doaj   +1 more source

Thymus Atrophy and Double-Positive Escape Are Common Features in Infectious Diseases

Journal of Parasitology Research, 2012
The thymus is a primary lymphoid organ in which bone marrow-derived T-cell precursors undergo differentiation, leading to migration of positively selected thymocytes to the T-cell-dependent areas of secondary lymphoid organs.
Juliana de Meis, Désio Aurélio Farias-de-Oliveira, Pedro H. Nunes Panzenhagen, Naiara Maran, Déa Maria Serra Villa-Verde, Alexandre Morrot, Wilson Savino   +6 more
doaj   +1 more source

Optimizing Cancer Vaccinations Using a Physiologically-Based Pharmacokinetic/Pharmacodynamic (PBPK/PD) Model. [PDF]

Adv Sci (Weinh)
Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
R Nikmaneshi M, P Padera T, L Munn L.
europepmc   +2 more sources

Multilevel human secondary lymphoid immune system compartmentalization revealed by complementary imaging approaches

iScience, 2023
Summary: Secondary human lymphoid tissue immune reactions take place in a highly coordinated environment with compartmentalization representing a fundamental feature of this organization.
Benjamin L. Oyler, Jeferson A. Valencia-Dávila, Eirini Moysi, Adam Molyvdas, Kalliopi Ioannidou, Kylie March, David Ambrozak, Laurence De Leval, Giulia Fabozzi, Amina S. Woods, Richard A. Koup, Constantinos Petrovas   +11 more
doaj   +1 more source

High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation

Frontiers in Immunology, 2016
High endothelial venules (HEVs) and lymphatic vessels (LVs) are essential for the function of the immune system, by providing communication between the body and lymph nodes (LNs), specialized sites of antigen presentation and recognition.
Nancy H Ruddle
doaj   +1 more source