The unexpected role of nurse shark pancreas as a secondary lymphoid organ [PDF]
Journal of ImmunologyAbstract Secondary lymphoid organs (SLOs) provide a structured environment to facilitate interactions between low frequency antigen-specific B and T cells as well as cognate antigen displayed by antigen presenting cells (APCs), resulting in the initiation of effective adaptive immune responses. The spleen is the most evolutionary ancient
Helen Dooley, Dooley Helen
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Tertiary lymphoid structure related B-cell IgE isotype switching and secondary lymphoid organ linked IgE production in mouse allergy model [PDF]
BMC Immunology, 2020 Background Numerous data obtained by different research laboratories indicate that specific IgE production is triggered independently of specific IgG or IgA ones and so it is not linked to fully matured germinal centers formation in the secondary ...
Dmitrii Borisovich Chudakov +5 more
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Development of Secondary Lymphoid Organs [PDF]
Annual Review of Immunology, 2008 Secondary lymphoid organs develop during embryogenesis or in the first few weeks after birth according to a highly coordinated series of interactions between newly emerging hematopoietic cells and immature mesenchymal or stromal cells. These interactions are orchestrated by homeostatic chemokines, cytokines, and growth factors that attract ...
Troy D Randall +2 more
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Natural killer cells in skin: a unique opportunity to better characterize the many facets of an overlooked secondary lymphoid organ [PDF]
Frontiers in ImmunologyNatural killer (NK) cells are lymphoid-derived cells that play a critical role in bridging innate and adaptive immunity. Given their ability to recognize and directly kill targets possessing missing or altered self-proteins and to induce indirect killing
Kirsten M. Johnson, Dean A. Lee
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Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions [PDF]
Nature Communications, 2018 Fibroblastic reticular cells (FRCs) are important regulators of T cell survival, proliferation, and migration in secondary lymphoid organs, but their role in HIV infection isn’t studied. Here, Murakami et al.
Tomoyuki Murakami +5 more
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Cell Reports, 2017 A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood.
Yotam E. Bar-Ephraim +12 more
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PG545 treatment reduces RRV-induced elevations of AST, ALT with secondary lymphoid organ alterations in C57BL/6 mice. [PDF]
PLoS ONE, 2019 Recently the anti-viral effects of prophylactic treatment with the low-molecular-weight heparan sulfate mimetic PG545 in Ross River virus (RRV) infected mice were reported.
Aroon Supramaniam +5 more
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iHALT unlocks liver functionality as a surrogate secondary lymphoid organ. [PDF]
NatureUpon viral infection, the current paradigm of humoral immunity posits that germinal centre reactions occurring within secondary lymphoid organs (SLOs) yield effector plasma cells that subsequently traffic to infected organs or the bone marrow1-3. However, it is not well understood how viral tissue tropism may govern the spatiotemporal dynamics of such ...
Gridley J +11 more
europepmc +3 more sources
Chicken Secondary Lymphoid Tissues—Structure and Relevance in Immunological Research
AnimalsRecent discoveries have indicated the importance of developing modern strategies for vaccinations, more ethical research models, and effective alternatives to antibiotic treatment in farm animals.
Cassandra Ceccopieri, Jan P. Madej
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Lessons of Vascular Specialization From Secondary Lymphoid Organ Lymphatic Endothelial Cells [PDF]
Circulation Research, 2023 Silvia Arroz-Madeira +2 more
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