Results 11 to 20 of about 57,576 (254)

Neutrophils in secondary lymphoid organs [PDF]

Immunology, 2021
AbstractNeutrophils are traditionally considered short‐lived, circulating innate immune cells that are rapidly recruited to sites of inflammation in response to infectious and inflammatory stimuli. Neutrophils efficiently internalize, kill or entrap pathogens, but their effector molecules may cause collateral tissue damage.
Lok, Laurence SC, Clatworthy, Menna R
openaire   +2 more sources

iHALT unlocks liver functionality as a surrogate secondary lymphoid organ. [PDF]

Nature
Upon viral infection, the current paradigm of humoral immunity posits that germinal centre reactions occurring within secondary lymphoid organs (SLOs) yield effector plasma cells that subsequently traffic to infected organs or the bone marrow1-3. However, it is not well understood how viral tissue tropism may govern the spatiotemporal dynamics of such ...
Gridley J, Pak D, Kumari A, Shupak J, Holland B, Shi Y, Trivedi S, Wang Y, Kasturi SP, Kapoor A, Chung RT, Grakoui A.   +11 more
europepmc   +3 more sources

Protective fibroblastic niches in secondary lymphoid organs

Journal of Experimental Medicine, 2023
Fibroblastic reticular cells (FRCs) are specialized fibroblasts of secondary lymphoid organs that provide the structural foundation of the tissue. Moreover, FRCs guide immune cells to dedicated microenvironmental niches where they provide lymphocytes and myeloid cells with homeostatic growth and differentiation factors.
Angelina De Martin, Yves Stanossek, Natalia Barbara Pikor, Burkhard Ludewig   +3 more
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Emergence and Evolution of Secondary Lymphoid Organs [PDF]

Annual Review of Cell and Developmental Biology, 2016
For effective adaptive immunity to foreign antigens (Ag), secondary lymphoid organs (SLO) provide the confined environment in which Ag-restricted lymphocytes, with very low precursor frequencies, interact with Ag on Ag-presenting cells (APC). The spleen is the primordial SLO, arising in conjunction with adaptive immunity in early jawed vertebrates. The
Harold R, Neely, Martin F, Flajnik
openaire   +2 more sources

The unexpected role of nurse shark pancreas as a secondary lymphoid organ. [PDF]

J Immunol
Abstract Secondary lymphoid organs (SLOs) provide a structured environment to facilitate interactions between low frequency antigen-specific B and T cells as well as cognate antigen displayed by antigen presenting cells (APCs), resulting in the initiation of effective adaptive immune responses. The spleen is the most evolutionary ancient
Hill TM, Dooley H.
europepmc   +3 more sources

Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation

Cell Reports, 2017
A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood.
Yotam E. Bar-Ephraim, Ferry Cornelissen, Natalie Papazian, Tanja Konijn, Remco M. Hoogenboezem, Mathijs A. Sanders, Bart A. Westerman, Mehmet Gönültas, Jaap Kwekkeboom, Joke M.M. Den Haan, Rogier M. Reijmers, Reina E. Mebius, Tom Cupedo   +12 more
doaj   +1 more source

Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2023
Lung cancer is the leading cause of cancer death, and non-small cell lung cancer (NSCLC) accounts for 85%. Immunotherapy has significantly improved the clinical prognosis of patients with NSCLC. However, because of the complexity and heterogeneousness of
Ying LIU, Lei XIONG, Ruoxue CAI, Yue CHEN, Jinjun YE, Bo SHEN, Guoren ZHOU   +6 more
doaj   +1 more source

Context-Dependent Development of Lymphoid Stroma from Adult CD34+ Adventitial Progenitors

Cell Reports, 2016
Despite the key role of primary and secondary lymphoid organ stroma in immunity, our understanding of the heterogeneity and ontogeny of these cells remains limited.
Katarzyna M. Sitnik, Kerstin Wendland, Holger Weishaupt, Heli Uronen-Hansson, Andrea J. White, Graham Anderson, Knut Kotarsky, William W. Agace   +7 more
doaj   +1 more source

Follicular dendritic cells, conduits, lymphatic vessels, and high endothelial venules in tertiary lymphoid organs: Parallels with lymph node stroma

Frontiers in Immunology, 2012
In this communication, the contribution of stromal, or non-hematopoietic, cells to the structure and function of lymph nodes (LNs), as canonical secondary lymphoid organs (SLOs), is compared to that of tertiary lymphoid tissue or organs (TLOs), also ...
Sharon eStranford, Nancy H. Ruddle
doaj   +1 more source

Controversial role of ILC3s in intestinal diseases: A novelty perspective on immunotherapy

Frontiers in Immunology, 2023
ILC3s have been identified as crucial immune regulators that play a role in maintaining host homeostasis and modulating the antitumor response. Emerging evidence supports the idea that LTi cells play an important role in initiating lymphoid tissue ...
Yunshu Zhang, Yunshu Zhang, Xuefei Feng, Juan Chen, Jiahao Liu, Jianmin Wu, Hongpei Tan, Ze Mi, Pengfei Rong, Pengfei Rong   +9 more
doaj   +1 more source