Results 101 to 110 of about 4,135,145 (344)

Non-Targeted Metabolomic Profiling Identifies Metabolites with Potential Antimicrobial Activity from an Anaerobic Bacterium Closely Related to Terrisporobacter Species.

, 2023
This work focused on the metabolomic profiling of the conditioned medium (FS03CM) produced by an anaerobic bacterium closely related to Terrisporobacter spp. to identify potential antimicrobial metabolites.
Brightwell G, Pahalagedara ASNW, Gupta TB, Flint S, Luo X, Palmer J, Li L   +6 more
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Heritable variation in root secondary metabolites is associated with recent climate [PDF]

, 2020
Plants can adapt to changing environments by adjusting the production and maintenance of diverse sets of bioactive secondary metabolites. To date, the impact of climatic conditions relative to other factors such as soil abiotic factors and herbivore ...
Erb, Matthias, Meret Huber, Arce, Carla C. M., Tobias Züst, Huber, Meret, Zoe Bont, Bont, Zoe, Züst, Tobias, Matthias Erb, Carla C. M. Arce   +9 more
core   +1 more source

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

ANTIBACTERIAL ACTIVITY OF A SECONDARY METABOLITE-PRODUCING CORAL BACTERIUM Pseudoalteromonas SPECIES [PDF]

, 2004
A bacterium, collected at the surface of coral Acropora sp., TAB4.2 was successfully screened for secondary metabolites production based on PCR amplification of the non-ribosomal peptide synthetase gene.
Karna Radjasa, Okky, Grossart, Hans-Peter, Sabdono, Agus, Marten, Torben, Brinkoff, Thorsten, Simon, Meinhard   +5 more
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Secondary metabolite research in Malaysia: current status and future prospects

, 2018
Herbal medicine is gaining acceptance worldwide for their effective pharmacological effects and relative safety. Plants have metabolic pathways that lead to the production and accumulation of secondary metabolites such as alkaloids, glycosides, and ...
Mohd. Salleh, Hamzah, Zainurin, Nur Aimi Aliah, Ahmad Fuad, Fazia Adyani, Noor Illi Mohamad Puad, Fazia Adyani Ahmad Fuad, Nur Aimi Aliah Zainurin, Hashim, Yumi Zuhanis Has-Yun, Mohamad Puad, Noor Illi, Yumi Zuhanis Has-Yun Hashim, Eissa, Manar, Hamzah Mohd. Salleh, Manar Eissa   +11 more
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Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

In vitro flowering in Oldenlandia umbellata L.

Journal of Ayurveda and Integrative Medicine, 2018
Background: Oldenlandia umbellata L. (Indian madder) is an antique Ayurvedic Indian herb and a source of various anthraquinone derivatives. The red dye from its roots has been used in diverse applications since ancient times.
Shuvra Kanta Behera, Chandrasekaran Rajasekaran, S. Payas, Devanand P. Fulzele, C. George Priya Doss, Ramamoorthy Siva   +5 more
doaj   +1 more source

Expression of secondary metabolites by the Mediterranean sponges Aplysina aerophoba and Aplysina cavernicola [PDF]

, 2008
Aplysina aerophoba and Aplysina cavernicola are two sibling sponge species common in Mediterranean sea. External and internal morphology is almost identical in the two species.
Majdi, Nabil
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