Proposing a fungal metabolite-Flaviolin as a potential inhibitor of 3CLpro of novel coronavirus SARS-CoV2 using docking and molecular dynamics [PDF]
arXiv, 2020 Here after performing docking and molecular dynamics of various small molecules derived as a secondary metabolite from fungi, we propose Flaviolin to act as potent inhibitor of 3-chymotrypsin (3C) like protease (3CLpro) of noval corona virus SARS-CoV2 responsible for pandemic condition caused by coronavirus disease 2019 (COVID-19).
arxiv
Metabolite mediated modeling of microbial community dynamics captures emergent behavior more effectively than species-species modeling [PDF]
, 2019 Personalized models of the gut microbiome are valuable for disease prevention and treatment. For this, one requires a mathematical model that predicts microbial community composition and the emergent behavior of microbial communities. We seek a modeling strategy that can capture emergent behavior when built from sets of universal individual ...
arxiv +1 more source
Chemistry of Secondary Metabolites
Annals of Clinical Toxicology, 2019 Medicinal plants, are known to deliver a wide scope of Plant Secondary Metabolites (PSMs) connected as bug sprays, medications, colors and poisons in farming, prescription, industry and biofighting in addition to bio-fear mongering, separately. Be that as it may, creation of PSMs is for the most part in little amounts, so we have to discover novel ...
openaire +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Quantifying the Dynamics of Bacterial Secondary Metabolites by Spectral Multiphoton Microscopy [PDF]
, 2011 Phenazines, a group of fluorescent small molecules produced by the bacterium Pseudomonas aeruginosa, play a role in maintaining cellular redox homeostasis. Phenazines have been challenging to study in vivo due to their redox activity, presence both intra-
Newman, Dianne +4 more
core +3 more sources
Tree defence and bark beetles in a drying world: carbon partitioning, functioning and modelling. [PDF]
, 2020 Drought has promoted large-scale, insect-induced tree mortality in recent years, with severe consequences for ecosystem function, atmospheric processes, sustainable resources and global biogeochemical cycles.
Almuth Hammerbacher +15 more
core +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Antifungal activity of microbial secondary metabolites. [PDF]
PLoS ONE, 2011 Secondary metabolites are well known for their ability to impede other microorganisms. Reanalysis of a screen of natural products using the Caenorhabditis elegans-Candida albicans infection model identified twelve microbial secondary metabolites capable ...
Jeffrey J Coleman +3 more
doaj +1 more source
Phytotoxic metabolites produced by Botryosphaeriaceae involved in grapevine trunk diseases [PDF]
, 2013 Fungi belonging to the Botryosphaeriaceae family are well known as cosmopolitan pathogens, saprophytes and endophytes and occur on a wide range of hosts including grapevine.
Andolfi, Anna +7 more
core
Induction of diverse secondary metabolites in Aspergillus fumigatus by microbial co-culture [PDF]
, 2013 Peer reviewedPublisher ...
Abraham +38 more
core +1 more source