Results 81 to 90 of about 3,826,489 (355)

Sensitivity of activated human lymphocytes to cyclosporine and its metabolites [PDF]

, 1988
Alloreactive T cells generated as clones from mixed lymphocyte cultures, or propagated from heart or liver transplant biopsies, were tested for secondary proliferation measured in the primed lymphocyte test in the presence of Cyclosporine A and ...
Burckart, G, Duquesnoy, RJ, Makowka, L, Murase, N, Starzl, TE, Van Thiel, DH, Venkataramanan, R, Wang, CP, Zeevi, A   +8 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Spring Abundance, Migration Patterns and Damaging Period of Aleyrodes proletella in the Czech Republic

Agronomy
The cabbage whitefly has become an important pest on brassica vegetables in Central Europe. It does not destroy the affected plants, but the product becomes unmarketable, causing considerable economic losses.
Kamil Holý, Kateřina Kovaříková
doaj   +1 more source

Correlation Between Secondary Metabolites of Leaf and the Resistance to Leaf Rust (Hemileia vastatrix) on Several Arabica Coffee Clones

Ilmu Pertanian (Agricultural Science), 2019
Indicator of coffee resistance to leaf rust attack (Hemileia vastatrix) is needed to select superior coffee plants resistant to biotic stress. This study aims to find the relationship between the content of secondary metabolites and the intensity of leaf
Gatot Subroto, Dwi Erwin Kusbianto, Sholeh Avivi, Slameto Slameto, Setiyono Setiyono   +4 more
doaj   +1 more source

Secondary metabolites in organic and conventional crops and diets, and their human bioavailability [PDF]

, 2010
The overall objective of the PhD project is to study the impact of growth system on the content of selected and presumably health-promoting bioactive secondary metabolites in certain crops of high abundance in the human diet.
Soeltoft, Malene
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Secondary Metabolites and Nutrient Balance in Casuarinas: an Insight Into Protein Competition Model (PCM) [PDF]

, 2014
The total phenolics, total condensed tannins (TCT), nitrogen (N) and total protein (TP) in needles of Casuarina equisetifolia and Casuarina junghuhniana were studied to understand the carbon-nutrient balance (CNB) and the growth-differentiation balance ...
Babu, D. S. (Devaraj), Murugesan, S. (Sourimuthu), Senthilkumar, N. (Natchiappan)   +2 more
core  

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Production of Secondary Metabolites in Extreme Environments: Food- and Airborne Wallemia spp. Produce Toxic Metabolites at Hypersaline Conditions [PDF]

, 2016
The food- and airborne fungal genus Wallemia comprises seven xerophilic and halophilic species: W. sebi, W. mellicola, W. canadensis, W. tropicalis, W. muriae, W. hederae and W. ichthyophaga.
Džeroski, Sašo, Frisvad, Jens Christian, Gostinčar, Cene, Gunde-Cimerman, Nina, Jančič, Sašo, Kocev, Dragi   +5 more
core   +2 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source