Results 21 to 30 of about 2,691,785 (114)

A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts

Genes to Cells, Volume 31, Issue 4, July 2026.
Double‐depleted Xenopus embryos of xMSX1 and xSEPTIN9 exhibited orofacial clefts, and wild‐type but not variants in human MSX1 and human SEPTIN9 mRNAs could rescue the phenotype of morphants, indicating that variants in MSX1 and SEPTIN9, each individually tolerated, synergistically disrupt craniofacial morphogenesis to cause orofacial clefts.
Udval Uuganbayar, Zarko Manojlovic, Nao Ito, Reiko Yamaguchi, Hiromasa Ninomiya, Issei S. Shimada, Chisato Yamada, Devin Feigelson, Gretchen Schulz, Allyn Auslander, Sylvia Rakotoarison, William Magee III, Yutaka Hashimoto, Yoichi Kato   +13 more
wiley   +1 more source

Junctional Neurulation: A Unique Developmental Program Shaping a Discrete Region of the Spinal Cord Highly Susceptible to Neural Tube Defects

, 2014
International audienceIn higher vertebrates, the primordium of the nervous system, the neural tube, is shaped along the rostrocaudal axis through two consecutive, radically different processes referred to as primary and secondary neurulation. Failures in
Catala, Martin, Escriou, Virginie, Duband, Jean-Loup, Dady, Alwyn, Havis, Emmanuelle   +4 more
core   +1 more source

Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives

iMeta, Volume 5, Issue 3, June 2026.
This review focuses on spatial omics, covering the introduction and comparison of technology platforms, explanation and recommendation of algorithm ecology, demonstration of biological applications, and prospect of large models. It aims to help researchers in the interdisciplinary field of spatial omics quickly understand the current situation and ...
Haoxiu Wang, Xinwang Yang, Siheng Wang, Zhe Yang, Xiuhui Yang, Yutong Yang, Zirong Li, Yuqi Ren, Qianqian Zhang, Bowen Zhao, Jingming Xiao, Yidong Wang, Junhao Dong, Zhenhao Kou, Jie Li, Liqun Yang, Erhu Zhao, Gregory Fonseca, Ruibang Luo, Mingyu Yang, Hongjuan Cui, Gengjie Jia, Dan Wang, Haoyang Li, Jun Ding, Zhiyuan Yuan, Haojing Shao   +26 more
wiley   +1 more source

Abnormal Enteric Nervous System Organization and Gastrointestinal Motility in Mice With Valproic Acid‐Induced Neural Tube Defects

Neurogastroenterology &Motility, Volume 38, Issue 6, June 2026.
Gastrointestinal tracts from fetuses with a valproic acid‐induced neural tube defect contain blood. Structurally, the enteric neuronal stripes are thinner with a narrower interstripe distance, leading to an increased number of stripes. Functionally, gastrointestinal motility is abnormal, with increased contraction frequency and increased length of ...
Gabrielle R. Barsh, Kelbi Banducci, Julia A. Kaltschmidt   +2 more
wiley   +1 more source

Morphogenic and Immunocytochemical Studies on Secondary Neurulation in the Mouse Embryo: Localization of Fibronectin and Laminin

, 1984
v, 42 p.The morphological changes involved in secondary neurulation, and the deposition and distribution of fibronectin and laminin during this process, were examined in mouse embryos (35-40 somites) using routine and immunocytochemical transmission ...
Murray, Susan M.
core   +1 more source

Rachipagus Parasitic Twin With Epithelialized Myelomeningocele in a Rural Ethiopian Neonate: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Rachipagus parasitic twinning is an exceptionally rare clinical entity resulting from an asymmetric monozygotic twinning process, characterized by a dorsally co‐joined partially formed twin. Co‐ existence of this condition with neural tube defect is uncommon, yet clinically significant.
Biruk Lealem, Elleni Tadesse, Bethelehem Engidawork   +2 more
wiley   +1 more source

Uncovering the Genetic Landscape of Spinal Dysraphism: A Retrospective Analysis of 150 Fetal Cases

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 849-861, May 2026.
ABSTRACT Objective Spinal dysraphism (SD) results from incomplete neural tube closure and encompasses a heterogeneous group of congenital anomalies with genetic and environmental etiologies. Although genetic contributions are recognized, causative variants remain insufficiently defined, and the clinical implications of extended genetic testing on ...
I. Bedei, A. Feresin, R. Zemet, D. Berner, D. Polidori, K. Fröbius, A. Skakkebæk, R. Axt‐Fliedner, M. Shoukier, C. Keil   +9 more
wiley   +1 more source

Efeito da homocisteína sobre os mecanismos celulares envolvidos na morfogênese da medula espinhal e do esqueleto axial de embriões de gallus domesticus: implicações na gênese dos efeitos do tubo neural [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2013O desequilíbrio no metabolismo do ácido fólico (AF) e da homocisteína (Hcy ...
Kobus, Karoline
core  

Neurulation and neural tube closure defects

, 2000
Tuan, R.S., Lo, C.W. (eds).The purpose of this chapter is to summarize some technical approaches and aspects of interpretation that are important when studying the process of neurulation and the origin of neural tube defects in mouse embryos.
Hynes, A., Fleming, A., Murdoch, J, Kolatsi-Joannou, M., Henderson, Deborah J., Copp, Andrew J., Gerrelli, D., Cogram, Patricia, Ybot, Patricia   +8 more
core   +1 more source

Exome Sequencing in Prenatally Diagnosed Isolated Neural Tube Defects: A Subtype‐Specific Analysis

Prenatal Diagnosis, Volume 46, Issue 5-6, Page 842-848, May 2026.
ABSTRACT Objective To explore potential genetic contributors across different subtypes of isolated neural tube defects (NTDs) ‐ acrania–exencephaly–anencephaly sequence (AEAS), spinal dysraphism, and encephalocele ‐ using exome sequencing (ES) in a prenatal cohort, with the goal of gaining insight into the molecular diversity underlying these distinct ...
Adi Botvinik, Vered Offen Glasner, Adi Reches, Hadas Miremberg, Karina Krajden Haratz, Tal brill, Liron Malki, Michal Rozenzwaig, Yuval Yaron, Michal Levy   +9 more
wiley   +1 more source