Results 31 to 40 of about 4,968,206 (256)

Multiple sclerosis: modern diagnostic markers and prognostic factors of disease progression

Сибирский научный медицинский журнал
Multiple sclerosis (MS) is one of the most common causes of disability in young people of working age. The prevalence of this disease has increased significantly in recent years and today amounts to more than 2 900 000 people worldwide.
A. I. Prokaeva, I. E. Arkhipov, E. E. Dorchinets, D. S. Korobko, N. A. Malkova   +4 more
doaj   +1 more source

Comparison of familial and sporadic multiple sclerosis in Iraqi patients

مجلة كلية الطب, 2012
Background: Multiple sclerosis (MS) is one of the increasing prevalent neurologic disorders. Epidemiologic and family studies implicate genetic and environmental factors in determining susceptibility to MS.
Hasan A. Al-hamadani, Hazim A. Marah, Farah Al-Saffar   +2 more
doaj   +1 more source

Clinical-MRI correlations in a European trial of interferon beta-1b in secondary progressive MS.

, 2001
Background: The recently completed placebo-controlled multicenter randomized trial of interferon beta-1b (Betaferon) in 718 patients with secondary progressive MS shows significant delay of disease progression and reduction of relapse rate.
Beckmann K, Yousry T, YOUSRY, T, BECKMANN, K, Thompson AJ, Filippi M, Barker GJ, Dahlke F, MacManus D, Barkhof F, MOLYNEUX, PD, POZZILLI, C, POLMAN, C, FILIPPI, M, Molyneux PD, MACMANUS, D; id_orcid, POZZILLI, Carlo, Polman C, DAHLKE, F, THOMPSON, AJ, European Study Group on Interferon Beta 1b in Secondary Progressive M.S., MILLER, DH, Hahn D, Wagner K, Barker, Gareth; id_orcid, WAGNER, K, KAPPOS, L, BARKHOF, F, Kappos L, HAHN, D, Miller DH, Ghazi M, GHAZI, M   +32 more
core   +1 more source

Progressive multiple sclerosis: Evaluating current therapies and exploring future treatment strategies

Neurotherapeutics
Progressive forms of multiple sclerosis (MS) include primary progressive MS (PPMS) and secondary progressive MS (SPMS). Unlike relapsing-remitting MS (RRMS), progressive MS is recognized by relentless progression with accumulating disability, rare to no ...
Marelisa Albelo-Martínez, Syed Rizvi
doaj   +1 more source

1H‐31P magnetic resonance spectroscopy: effect of biotin in multiple sclerosis

Annals of Clinical and Translational Neurology, 2019
Biotin is thought to improve functional impairment in progressive multiple sclerosis (MS) by upregulating bioenergetic metabolism. We enrolled 19 patients suffering from progressive MS (5 primary and 14 secondary Progressive‐MS).
Carole Guillevin, Pierre Agius, Mathieu Naudin, Guillaume Herpe, Stéphanie Ragot, Nicolas Maubeuge, Jean Philippe Neau, Rémy Guillevin   +7 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Comparison of familial and sporadic multiple sclerosis in Iraqi patients

مجلة كلية الطب, 2021
Background: Multiple sclerosis (MS) is one of the increasing prevalent neurologic disorders. Epidemiologic and family studies implicate genetic and environmental factors in determining susceptibility to MS.
Hasan A. Al-hamadani, Hazim A. Marah, Farah Al-Saffar   +2 more
doaj  

Predicting the On-Study Relapse Rate for Multiple Sclerosis Patients in Clinical Trials [PDF]

, 2005
Background: The annual relapse rate has been commonly used as a primary efficacy endpoint in phase III multiple sclerosis (MS) clinical trials. The aim of this study was to determine the relative contribution of different possible prognostic factors ...
Chang, C., Polman, Chris, Kappos, L., Polman, C., Held, U., Heigenhauser, L., Shang, C., Heigenhauser, Ludwig, Kappos, Ludwig   +8 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source