Results 61 to 70 of about 4,968,206 (256)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Safety of long-term intrathecal methotrexate in progressive forms of MS

Therapeutic Advances in Neurological Disorders, 2019
Background: There are few treatment options for multiple sclerosis (MS) patients with advanced disability [expanded disability status scale (EDSS) ⩾ 6.0].
James W. Stark, Lena Josephs, Deirdre Dulak, Madison Clague, Saud A. Sadiq   +4 more
doaj   +1 more source

VEGF levels were significantly higher in secondary progressive MS patients.

, 2015
Plasma levels of the vascular growth factor (VEGF) in the validation cohort, were higher in secondary progressive MS patients (SP-MS, n = 16) than in patients with the relapsing-remitting form (RR-MS, n = 38) and than in healthy controls (HC, n = 20 ...
Silvia Sánchez-Ramón (327324), Clara de Andrés (327318), Rocío Ramos-Medina (749126), Marta Tejera-Alhambra (749124), Lidia Fernández-Paredes (749128), Janet Vega (749127), Matthew L. Albert (200113), Armanda Casrouge (64698), Ansgar Seyfferth (749125), Bárbara Alonso (327320)   +9 more
core   +1 more source

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source

The Factors Associated With Olfactory Dysfunction in Patients with Multiple Sclerosis

Basic and Clinical Neuroscience, 2021
Introduction: An impaired sense of smell has a remarkable impact on the quality of life. It is seen in a variety of neurodegenerative diseases such as Parkinson disease.
Mostafa Almasi, Mohammad Ali Sahraian, Fahimeh Haji Akhoundi, Hamid Reza Ezzati, Mohammad Rohani   +4 more
doaj  

Two Sides to Every Story: Perspectives from Four Patients and a Healthcare Professional on Multiple Sclerosis Disease Progression

Neurology and Therapy, 2019
Multiple sclerosis (MS) is a chronic progressive disease and many patients transition from an initial relapsing–remitting course to a secondary progressive pattern. Accurate classification of disease status is critical to ensure that patients are treated
Jeri Burtchell, Kristen Fetty, Katelyn Miller, Kit Minden, Daniel Kantor   +4 more
doaj   +1 more source

Interferon beta-1b in secondary progressive MS: a combined analysis of the two trials

, 2004
BACKGROUND: A European (EU) and a North American (NA) placebo-controlled study with interferon beta-1b (IFNB-1b) in secondary progressive multiple sclerosis (SPMS) showed divergent results with regard to their primary outcome of sustained Expanded ...
BOARD, POLMAN C, WEINSHENKER B, THOMPSON AJ, BECKMANN K, MULTIPLE SCLEROSIS TRIAL STEERING COMMITTEE AND INDEPENDENT ADVISORY BOARD, DAHLKE F, NORTH AMERICAN NA SPMS INTERFERON BETA B. IN SECONDARY PROGRESSIVE, MCFARLAND H, EUROPEAN EU SPMS INTERFERON BETA B. IN SECONDARY, POZZILLI, Carlo, KAPPOS L, PROGRESSIVE MULTIPLE SCLEROSIS TRIAL STEERING COMMITTEE AND INDEPENDENT ADVISORY   +12 more
core  

Clinical and Modifiable Factors Associated With Disability and Relapse in MOGAD: A Multicentre Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Factors associated with relapse course and disability in myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) remain incompletely understood. Objectives To identify clinical and modifiable factors associated with relapse and disability in MOGAD. Methods In this ambispective multicentre cohort study using data from
Yingtao Wang, Shaoxin Tao, Qiujia Wang, Xiaoyu Xu, Hui Yao, Zheng Liu, Dawei Li, Zhandong Qiu, Jinming Han, Jiangwei Xia, Qi Wang, Jun Sun, Kai Shao, Jiao Li, Shishuang Ruan, Yi Zhong, Jun Guo, Shougang Guo, Yue Huang, Guoliang Chai, Tao Jin, Hongyu Zhou, Junwei Hao, Yinan Zhao   +23 more
wiley   +1 more source

A rapid review of differences in cerebrospinal neurofilament light levels in clinical subtypes of progressive multiple sclerosis

Frontiers in Neurology
BackgroundMultiple sclerosis (MS) is divided into three clinical phenotypes: relapsing–remitting MS (RRMS), secondary progressive MS (SPMS), and primary progressive MS (PPMS).
Haritha L. Desu, Haritha L. Desu, Katherine M. Sawicka, Katherine M. Sawicka, Katherine M. Sawicka, Emily Wuerch, Vanessa Kitchin, Jacqueline A. Quandt, Jacqueline A. Quandt   +8 more
doaj   +1 more source