Insulin secretagogue use and circulating inflammatory C–C chemokine levels in breast cancer patients
Data in Brief, 2017 Monocytes’ infiltration into the tumor tissue and their activation to tumor-associated macrophages is an essential step in tumor development, also playing a critical role in an eventual metastasis.
Zachary A.P. Wintrob +6 more
doaj +1 more source
Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
, 2018 Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael +8 more
core +3 more sources
Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target1,2,3
eNeuro, 2015 The growth hormone secretagogue receptor, a key component of the ghrelin system, is important in many processes, including feeding behavior, stress, and reward.
Martin K. Wellman, A. Abizaid
semanticscholar +1 more source
Efficacy of rebamipide 2% ophthalmic solution in the treatment of dry eyes
Oman Journal of Ophthalmology, 2018 AIM: The aim of this study is to evaluate the efficacy of 2% rebamipide ophthalmic solution on the tear functions and ocular surface status in patients with dry eyes.
Saurabh Shrivastava +4 more
doaj +1 more source
Antihyperglycemic and Insulin Secretagogue Activities of Abrus precatorius Leaf Extract
Pharmacognosy Research, 2016 Aim: Abrus precatorius leaves methanolic extract (APME) was evaluated for in vivo antihyperglycemic activity and in vitro insulinotropic effect. Materials and Methods: In vivo antihyperglycemic and insulin secretagogue activities were assessed in ...
B. Umamahesh, C. Veeresham
semanticscholar +1 more source
Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Frontiers in Pharmacology, 2022 Mitiglinide is a highly selective fast-acting anti-diabetic drug that induces insulin secretion by inhibiting pancreatic KATP channels. However, how mitiglinide binds KATP channels remains unknown.
Mengmeng Wang +9 more
doaj +1 more source
Interactions of chemostimuli at the single cell level: studies in a model system [PDF]
, 2004 The responses of afferent chemosensory fibres of the carotid body to individual chemostimuli have long been established. However, the mechanisms underlying the multiplicative interactions of these stimuli (i.e.
Peers, C.
core +1 more source
Evaluation and Diagnostic Potential of Serum Ghrelin in Feline Hypersomatotropism and Diabetes Mellitus [PDF]
, 2015 BACKGROUND: Ghrelin is a growth hormone secretagogue. It is a potent regulator of energy homeostasis. Ghrelin concentration is down‐regulated in humans with hypersomatotropism (HS) and increases after successful treatment. Additionally, ghrelin secretion
Appleton +42 more
core +1 more source
The Journal of comparative neurology, 2014 Growth hormone secretagogue receptor (GHSR) 1a is the only molecularly identified receptor for ghrelin, mediating ghrelin‐related effects on eating, body weight, and blood glucose control, among others. The expression pattern of GHSR within the brain has
Bharath K. Mani +7 more
semanticscholar +1 more source
Proteome Science, 2011 Background Neutrophils are abundant leukocytes that play a primary role in defence against pathogens. Neutrophils enter sites of infection where they eliminate pathogens via phagocytosis and the release of antimicrobial mediators via degranulation.
Eitzen Gary +5 more
doaj +1 more source