Results 101 to 110 of about 34,073 (255)

A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration

BMC Veterinary Research, 2012
Background Ghrelin is a natural ligand of the growth hormone secretagogue receptor (GHS-R). They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis may have an important role in ...
Majchrzak Kinga, Pawłowski Karol M, Orzechowska Emilia J, Dolka Izabella, Mucha Joanna, Motyl Tomasz, Król Magdalena   +6 more
doaj   +1 more source

Efficacy and safety of imeglimin add‐on to DPP‐4 inhibitor therapy in Japanese patients with type 2 diabetes mellitus: An interim analysis of the randomised, double‐blind FAMILIAR trial

Diabetes, Obesity and Metabolism, Volume 27, Issue 6, Page 3212-3222, June 2025.
Abstract Aims The ongoing FAMILIAR trial aims to provide evidence for clinical decision‐making and offer a novel treatment paradigm in type 2 diabetes mellitus (T2DM) management. The interim findings of FAMILIAR through Week 24 are reported. Materials and Methods FAMILIAR is a multicentre, randomised, double‐blind study comparing the efficacy and ...
Kohei Kaku, Masashi Shimoda, Takeshi Osonoi, Masahiro Iwamoto, Hideaki Kaneto   +4 more
wiley   +1 more source

Abnormal regulation of Na,K-ATPase in Glucose Intolerant Rats. [PDF]

, 2010
Introduction: Glucose is the most important physiological insulin secretagogue. However, the mechanisms underlying glucose-induced insulin release are not fully understood.
Antunes, Célia M., Costa, Ana Rodrigues, Cruz-Morais, Julio   +2 more
core  

Ghrelin and lipid metabolism: key partners in energy balance [PDF]

, 2010
Disclaimer: this is not the definitive version of record of this article. This manuscript has been accepted for publication in "Journal of Molecular Endocrinology", but the version presented here has not yet been copy-edited, formatted or proofed ...
Cordido, Fernando, Diéguez, Carlos, López, Miguel, Nogueiras, Rubén, Varela, Luis, Vidal-Puig, Antonio, Vázquez, María J.   +6 more
core   +2 more sources

Circulating adipokines data associated with insulin secretagogue use in breast cancer patients

Data in Brief, 2017
Oral drugs stimulating endogenous insulin production (insulin secretagogues) may have detrimental effects on breast cancer outcomes. The data presented shows the relationship between pre-existing insulin secretagogues use, adipokine profiles at the time ...
Zachary A.P. Wintrob, Jeffrey P. Hammel, George K. Nimako, Zahra S. Fayazi, Dan P. Gaile, Alan Forrest, Alice C. Ceacareanu   +6 more
doaj   +1 more source

Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.

Journal of Clinical Investigation, 2006
The growth hormone (GH) secretagogue receptor (GHSR) was cloned as the target of a family of synthetic molecules endowed with GH release properties. As shown recently through in vitro means, this receptor displays a constitutive activity whose clinical ...
J. Pantel, M. Legendre, S. Cabrol, L. Hilal, Yassir Hajaji, S. Morisset, S. Nivot, Marie-Pierre Vié-Luton, D. Grouselle, M. de Kerdanet, A. Kadiri, J. Epelbaum, Y. Le Bouc, S. Amselem   +13 more
semanticscholar   +1 more source

Ghrelin accelerates synapse formation and activity development in cultured cortical networks [PDF]

, 2014
Background: While ghrelin was initially related to appetite stimulation and growth hormone secretion, it also has a neuroprotective effect in neurodegenerative diseases and regulates cognitive function. The cellular basis of those processes is related to
Feber, J. le, Stoyanova, I.I.
core   +2 more sources

Growth Hormone Releasing Peptide 6 (GHRP6) reduces liver fibrosis in CCl4 chronically intoxicated rats

Biotecnología Aplicada
Tissue fibrosis is a leading cause of morbidity and mortality. Current treatments for conditions such as hepatic fibrosis have been unsuccessful. The growth hormone relasing peptide 6 (GHRP6) is endowed with cardioprotective actions but its antifibrotic ...
Jorge Berlanga-Acosta, Dania Vázquez-Blomquist, Danay Cibrián, Yssel Mendoza, María E Ochagavía, Jamilet Miranda, José Suárez, Yolanda González-Ferrer, José M Vila, Angel Abreu, Dayana Ugarte-Moreno, Yolanda Cruz, Ivon Howland, Rosa Coro-Antich, Olga S León, Ricardo Bringas, Diana García del Barco, Karelia Cosme-Díaz, Daniel Palenzuela, Julio R Fernández, Marcelo Nazabal, Isabel Guillén, Alberto Cintado, Lidia Inés, Ernesto López-Mola, Gerardo E Guillén-Nieto   +25 more
doaj  

Ghrelin accelerates growth of olfactory ensheathing cells through ERK pathway

Indian Journal of Animal Sciences, 2016
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), stimulates growth hormone (GH) secretion and has both orexigenic and adipogenic effects.
PEI ZHANG, L I RUIFENG, L V HUICHENG, YANXIANG TONG, ZHIQIANG CHANG, Y U BAOLONG, W U YIMIN   +6 more
doaj   +1 more source

Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes

Journal of Internal Medicine, Volume 297, Issue 6, Page 584-607, June 2025.
Abstract Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification of metabolites that are integral to the development of insulin resistance, a characteristic feature of cardiometabolic disease. Key metabolites, such as branched‐chain
David Rizo‐Roca, John D. Henderson, Juleen R. Zierath   +2 more
wiley   +1 more source