Objectives We aimed to determine if oral faecal microbiota transplantation improves indices of glycaemic control, changes the faecal dysbiosis indices, alters faecal short‐chain fatty acid and bile acid profiles and increases serum glucagon‐like‐peptide 1 concentrations in diabetic dogs.
R. Brown+10 more
wiley +1 more source
The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond
Ghrelin is a stomach-derived peptide hormone that acts via the growth hormone secretagogue receptor (GHSR) and displays a plethora of neuroendocrine, metabolic, autonomic and behavioral actions.
Mario Perelló+5 more
doaj
Hormone and Metabolite Changes associated with Extended Breeding Fasts in Male Northern Elephant Seals (Mirounga Angustirostris) [PDF]
We measured metabolic hormones and several key metabolites in breeding adult male northern elephant seals to examine the regulation of fuel metabolism during extended natural fasts of over 3 months associated with high levels of energy expenditure. Males
Costa, Daniel P.+4 more
core +1 more source
Skeletal Muscle Memory: An Update From the Antidoping Perspective
ABSTRACT This narrative review explores the concept of muscle memory, focusing on the physiological and biochemical mechanisms underlying information retention in skeletal muscle tissue as it relates to antidoping. The discussion encompasses the role of satellite cells (SCs) in myonuclei recruitment, resulting in increased myonuclear density and ...
Claire Traversa
wiley +1 more source
LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue
Kripa Shankar+12 more
semanticscholar +1 more source
Proteins are intrinsically flexible and thus require an ensemble description. In abstract conformer space, ensemble diversity is easier to assess and the required ensemble size can be established. Abstract Pairwise distance root mean square deviation defines a hyperspace where conformers with similar shape reside close to each other.
Gunnar Jeschke
wiley +1 more source
Ghrelin, food intake, and botanical extracts: A Review [PDF]
A kind of growth hormone secretagogue (GHS), ghrelin, was first isolated from the rat stomach and plays a major role in the activation of the growth hormone secretagogue receptor 1a (GHS-R1a) resulting the release of growth hormone (GH).
Peyman Rezaie+2 more
doaj
Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking [PDF]
In neurosecretory cells, secretory vesicles (SVs) undergo Ca2(+)-dependent fusion with the plasma membrane to release neurotransmitters. How SVs cross the dense mesh of the cortical actin network to reach the plasma membrane remains unclear.
Gomez, Guillermo A.+7 more
core +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood+3 more
wiley +1 more source
A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration
Background Ghrelin is a natural ligand of the growth hormone secretagogue receptor (GHS-R). They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis may have an important role in ...
Majchrzak Kinga+6 more
doaj +1 more source