Abnormal regulation of Na,K-ATPase in Glucose Intolerant Rats. [PDF]
, 2010 Introduction: Glucose is the most important physiological insulin secretagogue. However, the mechanisms underlying glucose-induced insulin release are not fully understood.
Antunes, Célia M. +2 more
core
Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes [PDF]
, 2013 Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes.
Blad C. C. +18 more
core +1 more source
Production by Secretagogues of Duodenal Ulcers in the Rat
Gastroenterology, 1970 Duodenal ulcers were produced in rats by subcutaneous infusion for 48 hr of either of the following secretagogues: histamine, carbachol, pentagastrin. When any two of these secretagogues were administered together, synergism was observed in the ulcerogenic effect. Synergism, or potentiation, is defined as an effect produced by two agents given together
James E. Dale +2 more
openaire +3 more sources
Predictors of Mortality in Patients With Multiple Endocrine Neoplasia Type 1
Clinical Endocrinology, Volume 103, Issue 1, Page 50-56, July 2025.SUMMARY Objective Multiple Endocrine Neoplasia Type 1 (MEN 1) is an autosomal dominant disease predisposing to hyperplasia and neoplasia in diverse endocrine tissues. Patients typically present with endocrine abnormalities before the age of 30 years and have reduced life expectancy.
Jasmine J. Zhu, John R Burgess
wiley +1 more source
Ghrelin accelerates growth of olfactory ensheathing cells through ERK pathway
Indian Journal of Animal Sciences, 2016 Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), stimulates growth hormone (GH) secretion and has both orexigenic and adipogenic effects.
PEI ZHANG +6 more
doaj +1 more source
Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation
Therapeutic Advances in Gastroenterology, 2018 Chronic constipation affects millions of Americans, consumes significant healthcare resources, and significantly affects quality of life (QOL). Recently, several new treatment options have become available for the treatment of constipation, including ...
Satish S.C. Rao
doaj +1 more source
Circulating adipokines data associated with insulin secretagogue use in breast cancer patients
Data in Brief, 2017 Oral drugs stimulating endogenous insulin production (insulin secretagogues) may have detrimental effects on breast cancer outcomes. The data presented shows the relationship between pre-existing insulin secretagogues use, adipokine profiles at the time ...
Zachary A.P. Wintrob +6 more
doaj +1 more source
Ghrelin causes hyperphagia and obesity in rats. [PDF]
, 2001 Ghrelin, a circulating growth hormone–releasing pep-tide derived from the stomach, stimulates food intake. The lowest systemically effective orexigenic dose of ghrelin was investigated and the resulting plasma ghre-lin concentration was compared with ...
Abbott, CR +10 more
core +1 more source
Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.
Journal of Clinical Investigation, 2006 The growth hormone (GH) secretagogue receptor (GHSR) was cloned as the target of a family of synthetic molecules endowed with GH release properties. As shown recently through in vitro means, this receptor displays a constitutive activity whose clinical ...
J. Pantel +13 more
semanticscholar +1 more source
Biological, Physiological, and Pharmacological Aspects of Ghrelin
Journal of Pharmacological Sciences, 2006 .: Ghrelin, identified as an endogenous ligand for the growth hormone secretagogue receptor, functions as a somatotrophic and orexigenic signal from the stomach.
Hiroshi Hosoda +2 more
doaj