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Ghrelin and synthetic GH secretagogues
Best Practice & Research Clinical Endocrinology & Metabolism, 2002Ghrelin, a 28-amino-acid acylated peptide, produced mainly by the stomach, displays strong growth hormone-(GH)-releasing activity mediated by the hypothalamus-pituitary growth hormone potential secretagogue (GHS) receptor which had been shown to be specific for a family of synthetic, orally active GHS.
ARVAT, Emanuela +6 more
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A Nonpeptidyl Growth Hormone Secretagogue
Science, 1993A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-{[2′-(1H-tetrazol-5-yl) (1,1′-biphenyl)-4-yl]methyl}-1H-1-benzazepin-3(R)-yl)-butanamide (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an ...
Roy G. Smith +12 more
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New non-sulfonylurea insulin secretagogues
Expert Opinion on Investigational Drugs, 1997Current treatments for non-insulin dependent diabetes mellitus (NIDDM) remain far from ideal. The universal finding of islet dysfunction characterised by the absence of first phase insulin secretion, even prior to the level of hyperglycaemia diagnostic of NIDDM, challenges the rationale for treatments that only enhance insulin action. To date, however,
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The Growth Hormone Secretagogue Receptor
2007The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
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Expert Opinion on Therapeutic Patents, 2000
Growth hormone secretagogues (GHSs) are synthetically produced peptides and non-peptides that stimulate growth hormone (GH) release by acting on one or more specific receptors. Treatment with GH itself is established in GH deficient children and adults and may also be useful in frail, elderly adults, in abdominally/viscerally obese subjects, in ...
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Growth hormone secretagogues (GHSs) are synthetically produced peptides and non-peptides that stimulate growth hormone (GH) release by acting on one or more specific receptors. Treatment with GH itself is established in GH deficient children and adults and may also be useful in frail, elderly adults, in abdominally/viscerally obese subjects, in ...
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Parenteral Nutrition: Substrate and Secretagogue
New England Journal of Medicine, 1972Maintenance of adequate nutrition in circumstances in which feeding via the gastrointestinal tract is precluded has been the subject of biologic inquiry since Caspar Sotus infused dogs with wine in 1664.1 In terms of current knowledge, the principles of intravenous nutrition can best be understood in the context of two types of clinical situations.
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1999
GH secretion is not infrequently low in normal elderly men and women and may compromise normal health (1,2). In the past, when a hormonal deficiency(s) was considered to be responsible for this decreased GH secretion in these subjects, a hypothalamic disorder rather than a pituitary disorder was proposed and a decreased secretion of GHRH or an ...
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GH secretion is not infrequently low in normal elderly men and women and may compromise normal health (1,2). In the past, when a hormonal deficiency(s) was considered to be responsible for this decreased GH secretion in these subjects, a hypothalamic disorder rather than a pituitary disorder was proposed and a decreased secretion of GHRH or an ...
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Growth Hormone Secretagogues: The Clinical Future
Hormone Research in Paediatrics, 1999Growth hormone (GH) releasing hexapeptide (GHRP)-6 and other peptidergic and non-peptidergic compounds collectively designated GH secretagogues (GHS) are potent releasers of GH in man. Their clinical future may be envisioned in three areas: therapy of GH-deficient (GHD) states, diagnosis of GHD, and non-endocrinological actions.
D, Micic +5 more
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Drugs, 1995
In recent years, several biosynthetic hexa- and heptapeptides, as well as nonpeptide bezolactam derivatives, have been found to be potent growth hormone (GH) secretagogues. They act synergistically with GH-releasing hormone (GHRH) but via different receptors, and are GHRH dependent.
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In recent years, several biosynthetic hexa- and heptapeptides, as well as nonpeptide bezolactam derivatives, have been found to be potent growth hormone (GH) secretagogues. They act synergistically with GH-releasing hormone (GHRH) but via different receptors, and are GHRH dependent.
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Growth hormone secretagogues astherapeutic agents
Growth Hormone & IGF Research, 1999Growth hormone (GH) treatment increases growth velocity in children with GH deficiency (GHD), ~ and reverses most of the abnormalities observed in adults with GHD. 2 GH treatment has also been found to reduce body fat in obese men, 3 increase muscle mass in men over 60 years of age, 4 and partially reverse the catabolic effects of dietary energy ...
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