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Growth hormone secretagogue receptor antagonists.
Expert opinion on therapeutic patents, 2012The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was disclosed that the addition in some compounds of a GlyMetAla tripeptide at the N-terminus of the ghrelin peptide agonists converts them into ghrelin receptor antagonists.
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IDrugs : the investigational drugs journal, 2005
Growth hormone secretagogues (GHSs) are a class of synthetic compounds that increase growth hormone secretion and serum IGF-1 concentrations. The short-acting GHSs produce transient elevations in GH which lead to little or no changes in IGF-1; the long-acting GHSs stimulate pulsatile GH release due to sustained elevations of IGF-1.
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Growth hormone secretagogues (GHSs) are a class of synthetic compounds that increase growth hormone secretion and serum IGF-1 concentrations. The short-acting GHSs produce transient elevations in GH which lead to little or no changes in IGF-1; the long-acting GHSs stimulate pulsatile GH release due to sustained elevations of IGF-1.
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Hypothalamic targets for growth hormone secretagogues
Acta Paediatrica, 1997Various novel growth hormone (GH) secretagogues have been developed. GH secretagogues release GH directly from the pituitary via a pathway distinct from that involving GH‐releasing hormone (GHRH). However, they also act centrally to activate hypothalamic neurones, and require an intact GHRH system for potent in vivo activity. Both normal and transgenic
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LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue
Molecular Metabolism, 2021Kripa Shankar +2 more
exaly
Nonpeptidyl Growth Hormone Secretagogues
1996The availability of recombinant human growth hormone (rhGH) in the mid1980s has fostered a renewed interest in potential clinical applications of growth hormone (GH). In addition to the treatment of GH-deficient children and adults, rhGH may have beneficial effects in the treatment of patients with burns, bone fractures, or Turner’s syndrome, in ...
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The ups and downs of growth hormone secretagogue receptor signaling
FEBS Journal, 2021Daniela Cassano +2 more
exaly
[Non-SU, insulin secretagogues].
Nihon rinsho. Japanese journal of clinical medicine, 1999The chemical structures, mechanisms of actions, bioavailabilities, insulinotrophic and hypoglycemic actions, and clinical trials of three novel oral hypoglycemic agents, NN-623, A-4166 and KAD-1229 are overviewed. They are non-SU insulin secretagogues and they induce quicker and shorter hypoglycemia than sulphonylureas do, presumably because they are ...
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