Activation of the Calcium Sensing Receptor Decreases Secretagogue-Induced Fluid Secretion in the Rat Small Intestine [PDF]
Frontiers in Physiology, 2019 BackgroundThe calcium-sensing receptor (CaSR) has been localized and characterized in numerous tissues throughout the body. In the mammalian gastrointestinal tract, the CaSR is known to act as a nutrient sensor and has recently been found to play a role ...
Maria J. Barahona +10 more
doaj +2 more sources
Restoring the mucin barrier: Advances in secretagogue therapies for ocular surface disorders [PDF]
Taiwan Journal of OphthalmologyMucins are essential components of the ocular surface, ensuring epithelial protection, tear film stability, and immune regulation. Mucin deficiency contributes to a spectrum of ocular surface disorders, including dry eye disease, allergic conjunctivitis,
Ya-Ning Chuang +5 more
doaj +2 more sources
Myricetin Amplifies Glucose–Stimulated Insulin Secretion via the cAMP-PKA-Epac-2 Signaling Cascade [PDF]
BiomedicinesAim: Myricetin, a natural bioflavonoid, is reported as an anti-diabetic agent since it possesses the ability to inhibit α-glucosidase activity, stimulate insulin action and secretion, manage ROS, and prevent diabetes complications.
Akhtar Ali +5 more
doaj +2 more sources
PDE-10A inhibitors as insulin secretagogues
Bioorganic & Medicinal Chemistry Letters, 2007 Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit increased insulin secretion.
Louis-David, Cantin +27 more
openaire +3 more sources
Real-world incidence and risk factors of level 3 (severe) hypoglycaemia in adults with type 1 or 2 diabetes (iNPHORM, United States). [PDF]
Diabetes Obes MetabAbstract Aims Level 3 (severe) hypoglycaemia is a serious, yet preventable, complication of insulin‐ or secretagogue‐treated diabetes. However, real‐world insight into its incidence and risk factors remains limited. We analysed data from the iNPHORM study to address this gap.
Ratzki-Leewing A +8 more
europepmc +2 more sources
The synthesis of a small library of prospective growth hormone secretagogues [PDF]
Journal of the Serbian Chemical Society, 1999 Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues.
JELENA JOKSIMOVIC +2 more
doaj +2 more sources
An animal study on the effect of topically administered ambroxol for dry eye
Frontiers in Bioscience-Landmark, 2022 Objective: To evaluate the effect of 0.2% ambroxol eye drop on tear secretion and corneal healing on a rabbit dry eye model, and to delineate potential underlying mechanisms.
Zixuan Wang +4 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are associated with elevated brain tissue excitability. We recently demonstrated that astrocytes, but not neurons, rapidly swell in elevated extracellular potassium (∧[K+]
Erin Walch +12 more
doaj +1 more source
Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. [PDF]
PLoS ONE, 2012 An early feature of acute pancreatitis is activation of zymogens, such as trypsinogen, within the pancreatic acinar cell. Supraphysiologic concentrations of the hormone cholecystokinin (CCK; 100 nM), or its orthologue cerulein (CER), induce zymogen ...
Thomas R Kolodecik +5 more
doaj +1 more source