Results 11 to 20 of about 34,970 (301)
Berberine is an insulin secretagogue targeting the KCNH6 potassium channel
Nature Communications, 2021 Berberine is a compound with glucose-lowering effects in mice and humans. Here, the authors show that in mice berberine has beneficial glycemic effects by promoting insulin secretion, which requires the potassium channel KCNH6 in beta cells, and that ...
Miao-Miao Zhao +11 more
doaj +2 more sources
The synthesis of a small library of prospective growth hormone secretagogues [PDF]
Journal of the Serbian Chemical Society, 1999 Employing tools of combinatorial chemistry, an original methodological approach has been developed and applied for the design and synthesis of a small library of peptide-like compounds, prospective growth hormone (GH) secretagogues.
JELENA JOKSIMOVIC +2 more
doaj +4 more sources
Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism
Cell Reports, 2015 Pancreatic islet failure, involving loss of glucose-stimulated insulin secretion (GSIS) from islet β cells, heralds the onset of type 2 diabetes (T2D). To search for mediators of GSIS, we performed metabolomics profiling of the insulinoma cell line 832 ...
Jessica R. Gooding +8 more
doaj +2 more sources
Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. [PDF]
PLoS ONE, 2012 An early feature of acute pancreatitis is activation of zymogens, such as trypsinogen, within the pancreatic acinar cell. Supraphysiologic concentrations of the hormone cholecystokinin (CCK; 100 nM), or its orthologue cerulein (CER), induce zymogen ...
Thomas R Kolodecik +5 more
doaj +2 more sources
Myricetin Amplifies Glucose–Stimulated Insulin Secretion via the cAMP-PKA-Epac-2 Signaling Cascade [PDF]
BiomedicinesAim: Myricetin, a natural bioflavonoid, is reported as an anti-diabetic agent since it possesses the ability to inhibit α-glucosidase activity, stimulate insulin action and secretion, manage ROS, and prevent diabetes complications.
Akhtar Ali +5 more
doaj +2 more sources
Central effect of ghrelin, an endogenous growth hormone secretagogue, on hypothalamic peptide gene expression. [PDF]
Endocrinology, 2000 Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHS-R), was originally purified from the rat stomach. Like the synthetic GHSs, ghrelin specifically releases GH following intravenous administration.
J. Kamegai +5 more
semanticscholar +3 more sources
FGF21 Is an Exocrine Pancreas Secretagogue. [PDF]
Cell Metabolism, 2017 The metabolic stress hormone FGF21 is highly expressed in exocrine pancreas, where its levels are increased by refeeding and chemically induced pancreatitis. However, its function in the exocrine pancreas remains unknown. Here, we show that FGF21 stimulates digestive enzyme secretion from pancreatic acinar cells through an autocrine/paracrine mechanism
K. Coate +7 more
semanticscholar +4 more sources
An animal study on the effect of topically administered ambroxol for dry eye
Frontiers in Bioscience-Landmark, 2022 Objective: To evaluate the effect of 0.2% ambroxol eye drop on tear secretion and corneal healing on a rabbit dry eye model, and to delineate potential underlying mechanisms.
Zixuan Wang +4 more
doaj +1 more source
The ups and downs of growth hormone secretagogue receptor signaling
The FEBS Journal, 2021 The growth hormone secretagogue receptor (GHSR) has emerged as one of the most fascinating molecules from the perspective of neuroendocrine control. GHSR is mainly expressed in the pituitary and the brain, and plays key roles regulating not only growth ...
M. Cornejo +5 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2022 Rapid increases in cell volume reduce the size of the extracellular space (ECS) and are associated with elevated brain tissue excitability. We recently demonstrated that astrocytes, but not neurons, rapidly swell in elevated extracellular potassium (∧[K+]
Erin Walch +12 more
doaj +1 more source