Results 271 to 280 of about 34,970 (301)
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Rapid Communications in Mass Spectrometry, 2010
GHRP-2 (pralmorelin, D-Ala-D-(beta-naphthyl)-Ala-Ala-Trp-D-Phe-Lys-NH(2)), which belongs to a class of growth hormone secretagogue (GHS), is intravenously used to diagnose growth hormone (GH) deficiency.
M. Okano +3 more
semanticscholar +1 more source
GHRP-2 (pralmorelin, D-Ala-D-(beta-naphthyl)-Ala-Ala-Trp-D-Phe-Lys-NH(2)), which belongs to a class of growth hormone secretagogue (GHS), is intravenously used to diagnose growth hormone (GH) deficiency.
M. Okano +3 more
semanticscholar +1 more source
The Growth Hormone Secretagogue Receptor
2007The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
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PDE-10A inhibitors as insulin secretagogues
Bioorganic & Medicinal Chemistry Letters, 2007Modulation of cAMP levels has been linked to insulin secretion in preclinical animal models and in humans. The high expression of PDE-10A in pancreatic islets suggested that inhibition of this enzyme may provide the necessary modulation to elicit increased insulin secretion.
Steven Magnuson +27 more
openaire +3 more sources
Expert Opinion on Therapeutic Patents, 2000
Growth hormone secretagogues (GHSs) are synthetically produced peptides and non-peptides that stimulate growth hormone (GH) release by acting on one or more specific receptors. Treatment with GH itself is established in GH deficient children and adults and may also be useful in frail, elderly adults, in abdominally/viscerally obese subjects, in ...
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Growth hormone secretagogues (GHSs) are synthetically produced peptides and non-peptides that stimulate growth hormone (GH) release by acting on one or more specific receptors. Treatment with GH itself is established in GH deficient children and adults and may also be useful in frail, elderly adults, in abdominally/viscerally obese subjects, in ...
openaire +2 more sources
Drug News and Perspectives, 2010
There exists a substantial need to identify new neuropharmacological targets to treat alcohol-dependent individuals. Ghrelin represents a gut-brain peptide, initially discovered as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R)
L. Leggio
semanticscholar +1 more source
There exists a substantial need to identify new neuropharmacological targets to treat alcohol-dependent individuals. Ghrelin represents a gut-brain peptide, initially discovered as the endogenous ligand for the growth hormone secretagogue receptor (GHS-R)
L. Leggio
semanticscholar +1 more source
1999
GH secretion is not infrequently low in normal elderly men and women and may compromise normal health (1,2). In the past, when a hormonal deficiency(s) was considered to be responsible for this decreased GH secretion in these subjects, a hypothalamic disorder rather than a pituitary disorder was proposed and a decreased secretion of GHRH or an ...
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GH secretion is not infrequently low in normal elderly men and women and may compromise normal health (1,2). In the past, when a hormonal deficiency(s) was considered to be responsible for this decreased GH secretion in these subjects, a hypothalamic disorder rather than a pituitary disorder was proposed and a decreased secretion of GHRH or an ...
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Mechanisms of Action of Nonglucose Insulin Secretagogues
Annual Review of Nutrition, 1994Insulin release induced by nonglucose secretagogues is initiated from beta-cell by a wide variety of stimuli through specific receptors or binding sites. Activation of receptors in turn generates or enhances the cytosol levels of cAMP, cADPR, IP3, DAG, and AA. These second messengers then activate protein kinases, change the ion currents cross the cell
Y Liang, F M Matschinsky
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Journal of Agricultural and Food Chemistry, 2011
The effect of lotus leaf ( Nelumbo nucifera Gaertn.) on diabetes is unclear. We hypothesized that lotus leaf can regulate insulin secretion and blood glucose levels.
Chun-Fa Huang +6 more
semanticscholar +1 more source
The effect of lotus leaf ( Nelumbo nucifera Gaertn.) on diabetes is unclear. We hypothesized that lotus leaf can regulate insulin secretion and blood glucose levels.
Chun-Fa Huang +6 more
semanticscholar +1 more source
Growth Hormone Secretagogues and Hypothalamic Networks
Endocrine, 2001Growth hormone secretagogues (GHSs) act at distinct levels to control growth hormone (GH) secretion. At the pituitary level they reinforce or extend a tonic GH-releasing-hormone (GHRH)-induced activated state by mobilizing intracellular Ca2+ store. At the hypothalamic level GHS actions are more complex than originally anticipated.
Constance Hammond +9 more
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Action Mechanisms of Secretagogue Drugs [PDF]
, 1984 A large number of agents with laxative or diarrheal effects have been shown to influence intestinal fluid and electrolyte transfer. They inhibit the absorption of electrolytes and water and they can also cause an accumulation of fluid within the intestinal lumen.
G. Nell, W. Rummel
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