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Additive effects of ileal secretagogues in the rat
Gastroenterology, 1990Although clinical diarrhea is often caused by more than one enteropathogen, it is not known whether secretagogues have additive effects on secretion. This question was examined in anesthetized, ventilated rats by exposing the ileum to secretory agents with different mechanisms of action.
Alan N. Charney, Hayes M. Dansky
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New non-sulfonylurea insulin secretagogues
Expert Opinion on Investigational Drugs, 1997Current treatments for non-insulin dependent diabetes mellitus (NIDDM) remain far from ideal. The universal finding of islet dysfunction characterised by the absence of first phase insulin secretion, even prior to the level of hyperglycaemia diagnostic of NIDDM, challenges the rationale for treatments that only enhance insulin action. To date, however,
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Hypothalamic targets for growth hormone secretagogues
Acta Paediatrica, 1997Various novel growth hormone (GH) secretagogues have been developed. GH secretagogues release GH directly from the pituitary via a pathway distinct from that involving GH‐releasing hormone (GHRH). However, they also act centrally to activate hypothalamic neurones, and require an intact GHRH system for potent in vivo activity. Both normal and transgenic
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Nonpeptidyl Growth Hormone Secretagogues
1996The availability of recombinant human growth hormone (rhGH) in the mid1980s has fostered a renewed interest in potential clinical applications of growth hormone (GH). In addition to the treatment of GH-deficient children and adults, rhGH may have beneficial effects in the treatment of patients with burns, bone fractures, or Turner’s syndrome, in ...
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Growth hormone secretagogues astherapeutic agents
Growth Hormone & IGF Research, 1999Growth hormone (GH) treatment increases growth velocity in children with GH deficiency (GHD), ~ and reverses most of the abnormalities observed in adults with GHD. 2 GH treatment has also been found to reduce body fat in obese men, 3 increase muscle mass in men over 60 years of age, 4 and partially reverse the catabolic effects of dietary energy ...
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Receptors for Secretagogues on Pancreatic Acinar Cells [PDF]
Journal of Pediatric Gastroenterology and Nutrition, 1980 J. D. Gardner, R. T. Jensen
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Growth Hormone Secretagogues in Critical Illness
Hormone Research in Paediatrics, 1999Alterations within the somatotropic axis occurring during the course of critical illness follow a biphasic pattern. The initial stress response consists of activated growth hormone (GH) release whereas circulating levels of GH-dependent insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 fall and IGFBP-1 concentrations rise.
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