Results 21 to 30 of about 15,945 (227)

SUN-092 Oral Growth Hormone Secretagogue (LUM-201) Pediatric Capsule Formulation Demonstrates Similar Pharmacokinetic (PK) Bioavailability and Pharmacodynamic (PD) Responses to Current Tablet Formulation [PDF]

J Endocr Soc
Erik L. Brincks, Apurvasena Parikh, Melissa Quesnot, Christopher M. Smith, Ronald Christopher, John C. McKew, Aleksandra K. Bruchey   +6 more
europepmc   +3 more sources

Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD <i>mdx:utrn</i>^-/- Mice, and Correlates Strongly with Inflammatory Markers, and Negatively with Cardiac Function. [PDF]

Cells
Naghibosadat M, McClennan A, Egiian M, Flynn-Rizk R, Lalonde T, Charron C, Chhabra A, Luyt LG, Dhanvantari S, Hoffman LM.   +9 more
europepmc   +3 more sources

Blocking Kir6.2 channels with SpTx1 potentiates glucose-stimulated insulin secretion from murine pancreatic β cells and lowers blood glucose in diabetic mice

eLife, 2022
ATP-sensitive K+ (KATP) channels in pancreatic β cells are comprised of pore-forming subunits (Kir6.2) and modulatory sulfonylurea receptor subunits (SUR1). The ATP sensitivity of these channels enables them to couple metabolic state to insulin secretion
Yajamana Ramu, Jayden Yamakaze, Yufeng Zhou, Toshinori Hoshi, Zhe Lu   +4 more
doaj   +1 more source

GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent Signaling. [PDF]

PLoS ONE, 2016
GPR142 is an islet-enriched G protein-coupled receptor that has been investigated as a novel therapeutic target for the treatment of type 2 diabetes by virtue of its insulin secretagogue activity.
Jingru Wang, Juan J Carrillo, Hua V Lin
doaj   +1 more source

Metabolomic Alteration in the Mouse Distal Colonic Mucosa after Oral Gavage with Oxalobacter formigenes

Metabolites, 2020
Oxalobacter formigenes has been investigated for years due to its proposed ability to produce a secretagogue compound that initiates net intestinal oxalate secretion, thereby theoretically reducing circulating oxalate and risk of kidney stone formation ...
Casey A. Chamberlain, Marguerite Hatch, Timothy J. Garrett   +2 more
doaj   +1 more source

Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies. [PDF]

PLoS ONE, 2015
It was recently reported that factor H, a regulatory component of the alternative complement pathway, is stored with von Willebrand factor (VWF) in the Weibel-Palade bodies of endothelial cells.
Nancy A Turner, Sarah E Sartain, Shiu-Ki Hui, Joel L Moake   +3 more
doaj   +1 more source

Pic Protein From Enteroaggregative E. coli Induces Different Mechanisms for Its Dual Activity as a Mucus Secretagogue and a Mucinase

Frontiers in Immunology, 2020
A hallmark of enteroaggregative Escherichia coli (EAEC) infection is the formation of an intestinal biofilm, which comprises a mucus layer with immersed bacteria. Pic is an autotransporter secreted by EAEC, and other E.
Fernando Flores-Sanchez, Lucia Chavez-Dueñas, Javier Sanchez-Villamil, Fernando Navarro-Garcia   +3 more
doaj   +1 more source

Mapping organelle motion reveals a vesicular conveyor belt spatially replenishing secretory vesicles in stimulated chromaffin cells. [PDF]

PLoS ONE, 2014
How neurosecretory cells spatially adjust their secretory vesicle pools to replenish those that have fused and released their hormonal content is currently unknown.
Guillaume Maucort, Ravikiran Kasula, Andreas Papadopulos, Timo A Nieminen, Halina Rubinsztein-Dunlop, Frederic A Meunier   +5 more
doaj   +1 more source

Berberine is an insulin secretagogue targeting the KCNH6 potassium channel

Nature Communications, 2021
Berberine is a compound with glucose-lowering effects in mice and humans. Here, the authors show that in mice berberine has beneficial glycemic effects by promoting insulin secretion, which requires the potassium channel KCNH6 in beta cells, and that ...
Miao-Miao Zhao, Jing Lu, Sen Li, Hao Wang, Xi Cao, Qi Li, Ting-Ting Shi, Kohichi Matsunaga, Chen Chen, Haixia Huang, Testuro Izumi, Jin-Kui Yang   +11 more
doaj   +1 more source

A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agen. [PDF]

PLoS ONE, 2016
Insulin secretagogues are used for treatment of type 2 diabetes. We attempted to discover novel small molecules to stimulate insulin secretion by using in silico similarity search using sulfonylureas as query, followed by measurement of insulin secretion.
Kenji Sugawara, Kohei Honda, Yoshie Reien, Norihide Yokoi, Chihiro Seki, Harumi Takahashi, Kohtaro Minami, Ichiro Mori, Akio Matsumoto, Haruaki Nakaya, Susumu Seino   +10 more
doaj   +1 more source