Results 21 to 30 of about 34,970 (301)
Interleukin-1 is a mucus secretagogue
Cellular Immunology, 1991 Explant cultures of mouse duodenum were used to show that interleukin-1 (IL-1) causes release of mucus from epithelial goblet cells. Our experiments made use of a newly described enzyme-linked lectin assay (ELLA) which employs enzyme-conjugated soybean agglutinin to detect mucus glycoproteins secreted from explant cultures of mouse duodenum ...
Victoria L. Cohan +3 more
openalex +4 more sources
GPR142 Agonists Stimulate Glucose-Dependent Insulin Secretion via Gq-Dependent Signaling. [PDF]
PLoS ONE, 2016 GPR142 is an islet-enriched G protein-coupled receptor that has been investigated as a novel therapeutic target for the treatment of type 2 diabetes by virtue of its insulin secretagogue activity.
Jingru Wang, Juan J Carrillo, Hua V Lin
doaj +1 more source
eLife, 2022 ATP-sensitive K+ (KATP) channels in pancreatic β cells are comprised of pore-forming subunits (Kir6.2) and modulatory sulfonylurea receptor subunits (SUR1). The ATP sensitivity of these channels enables them to couple metabolic state to insulin secretion
Yajamana Ramu +4 more
doaj +1 more source
Frontiers in Immunology, 2020 A hallmark of enteroaggregative Escherichia coli (EAEC) infection is the formation of an intestinal biofilm, which comprises a mucus layer with immersed bacteria. Pic is an autotransporter secreted by EAEC, and other E.
Fernando Flores-Sanchez +3 more
doaj +1 more source
Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies. [PDF]
PLoS ONE, 2015 It was recently reported that factor H, a regulatory component of the alternative complement pathway, is stored with von Willebrand factor (VWF) in the Weibel-Palade bodies of endothelial cells.
Nancy A Turner +3 more
doaj +1 more source
Metabolites, 2020 Oxalobacter formigenes has been investigated for years due to its proposed ability to produce a secretagogue compound that initiates net intestinal oxalate secretion, thereby theoretically reducing circulating oxalate and risk of kidney stone formation ...
Casey A. Chamberlain +2 more
doaj +1 more source
Mapping organelle motion reveals a vesicular conveyor belt spatially replenishing secretory vesicles in stimulated chromaffin cells. [PDF]
PLoS ONE, 2014 How neurosecretory cells spatially adjust their secretory vesicle pools to replenish those that have fused and released their hormonal content is currently unknown.
Guillaume Maucort +5 more
doaj +1 more source
Pharmacogenetics of insulin secretagogue antidiabetics [PDF]
Orvosi Hetilap, 2011 Type 2 diabetes is making up to 90% of the all diabetic cases. In addition to insulin resistance, insufficient B-cell function also plays an important role in the pathogenesis of the disease. The insufficient production and secretion of insulin can be increased by secretagogue drugs, like sulfonylureas and incretin mimetics/enhancers.
Gábor Winkler, Gerö L
openaire +3 more sources
Ghrelin axis genes, peptides and receptors : recent findings and future challenges [PDF]
, 2011 The ghrelin axis consists of the gene products of the ghrelin gene (GHRL), and their receptors, including the classical ghrelin receptor GHSR. While it is well-known that the ghrelin gene encodes the 28 amino acid ghrelin peptide hormone, it is now also ...
Seim, Inge +4 more
core +2 more sources
Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]
, 2013 The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre +3 more
core +5 more sources